Introduction In the past 20+ years, several studies of bovine embryo production showed how
the ratio of male to female embryos changes if embryos are made in vivo or in vitro. It is …

Non-invasive analysis of bovine embryo metabolites during in vitro embryo culture using
nuclear magnetic resonance Page 1 AIMS Bioengineering, 3(4): 538-551. DOI: 10.3934/bioeng.2016.4.538 …

Introduction Bovine female and male embryos differentially release metabolites with
signalling effects to culture media. However, it is unknown if the embryo-maternal interface …

OBJECTIVE: To identify biomarkers associated with reproductive outcome using proton
nuclear magnetic resonance (1H NMR) metabolomic profiling of embryo culture media …

Infertility affects approximately 15–20% of individuals of reproductive age worldwide. Over
the last 40 years, assisted reproductive technology (ART) has helped millions of childless …

Object The prediction of embryo viability by usual morphological analysis is currently
unsatisfactory. New non-invasive techniques such as high-resolution nuclear magnetic …

NMR offers the potential to holistically screen hundreds of metabolites and has already
proved to be a powerful technique able to provide a global picture of metabolic changes in a …

Spent culture medium can provide valuable information regarding the physiological state of
a bovine preimplantation embryos through non-invasive analysis of the sum/depleted …

The in vitro production of bovine embryos has dramatically increased in recent years. From
the first calves produced entirely from IVEP (in vitro embryo production) until today, the in …

Introduction Different gene expression between male and female bovine embryos leads to
metabolic differences. Objective We used UHPLC-MS/MS to identify sex metabolite …