Aside from glucose metabolism, insulin regulates a variety of pathways in peripheral tissues.
Under insulin-resistant conditions, it is well known that insulin-stimulated glucose uptake is …

Insulin resistance is a manifestation of both diabetes mellitus and obesity. However, the
mechanism is still not clearly identified. Herein, we describe a procedure that allows us to …

Although the importance of adipose tissue (AT) glucose transport in regulating whole-body
insulin sensitivity is becoming increasingly evident and insulin resistance (IR) has been …

Insulin stimulates muscle and adipose tissue to absorb glucose through a signaling cascade
that is incompletely understood. Insulin resistance, the inability of insulin to appropriately …

The aim of this study was to investigate whether high glucose and/or high insulin produces
cellular insulin resistance in human adipocytes and, if so, to evaluate the time course and …

Decreased GLUT4 expression, impaired insulin receptor (IR), IRS‐1, and pp60/IRS‐3
tyrosine phosphorylation are characteristics of adi‐pocytes from insulin‐resistant animal …

Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …

Insulin-stimulated glucose uptake into muscle and adipose tissue is vital for maintaining
whole-body glucose homeostasis. Insulin promotes glucose uptake into these tissues by …

Type 2 diabetes originates in an expanding adipose tissue that for unknown reasons
becomes insulin resistant. Insulin resistance reflects impairments in insulin signaling, but …

Adipose tissue plays an important role in glucose homeostasis and affects insulin sensitivity
in other tissues. In obesity and type 2 diabetes, glucose transporter 4 (GLUT4) is …