The visualization of membrane protein complexes in their natural membrane environment is
a major goal in an emerging area of research termed structural cell biology. Such …

Unravelling the structural organization of membrane protein machines in their active state
and native lipid environment is a major challenge in modern cell biology research. Here we …

The complexity of biological membranes presents technical challenges for the analysis of
membrane protein biogenesis and function. Here we describe an in vitro fluorescence …

Mitochondria are responsible for maintaining a variety of cellular functions. One such
function is the interaction and subsequent import of proteins into these organelles via the …

The translocase of the mitochondrial outer membrane (TOM) complex is the main import
pore for nuclear-encoded proteins into mitochondria, yet little is known about its spatial …

Translocation of preproteins across the mitochondrial outer membrane is mediated by the
TOM complex. This complex consists of receptor components for the initial contact with …

Mitochondrial protein targeting includes both intramitochondrial sorting of proteins encoded
by the organellar genome and import and subsequent sorting of nuclear encoded precursor …

Mitochondrial protein import requires cooperation of the machineries called translocators in
the outer and inner mitochondrial membranes. Here we analyze the interactions of Tom22, a …

The mitochondrial translocase complex TIM23 targets several hundreds of proteins to their
location in the mitochondrial matrix or inner membrane. Recent studies provide important …

The mitochondrial inner membrane is a protein-rich environment containing large multimeric
complexes, including complexes of the mitochondrial electron transport chain, mitochondrial …