Metabolic engineering of Escherichia coli for the biosynthesis of various phenylpropanoid derivatives

S Wang, S Zhang, A Xiao, M Rasmussen… - Metabolic …, 2015 - Elsevier
Plants produce a variety of natural products with promising biological activities, such as the
phenylpropanoids resveratrol and curcumin. While these molecules are naturally assembled …

Biosynthesis of plant-specific phenylpropanoids by construction of an artificial biosynthetic pathway in Escherichia coli

O Choi, CZ Wu, SY Kang, JS Ahn… - Journal of Industrial …, 2011 - academic.oup.com
Biological synthesis of plant secondary metabolites has attracted increasing attention due to
their proven or assumed beneficial properties and health-promoting effects …

Combinatorial biosynthesis of non-bacterial and unnatural flavonoids, stilbenoids and curcuminoids by microorganisms

S Horinouchi - The Journal of antibiotics, 2008 - nature.com
One of the approaches of combinatorial biosynthesis is combining genes from different
organisms and designing a new set of gene clusters to produce bioactive compounds …

Metabolic engineering of microorganisms for the production of natural compounds

SY Park, D Yang, SH Ha, SY Lee - Advanced Biosystems, 2018 - Wiley Online Library
Natural products have been attracting much interest around the world for their diverse
applications, especially in drug and food industries. Plants have been a major source of …

New frontiers: harnessing pivotal advances in microbial engineering for the biosynthesis of plant-derived terpenoids

MS Belcher, J Mahinthakumar, JD Keasling - Current opinion in …, 2020 - Elsevier
Highlights•Terpenoids are a vast and diverse class of compounds with applications in both
the industrial and human health spaces.•Computational biology and gene discovery enable …

Engineered biosynthesis of natural products in heterologous hosts

Y Luo, BZ Li, D Liu, L Zhang, Y Chen, B Jia… - Chemical Society …, 2015 - pubs.rsc.org
Natural products produced by microorganisms and plants are a major resource of
antibacterial and anticancer drugs as well as industrially useful compounds. However, the …

Combinatorial biosynthesis of plant medicinal polyketides by microorganisms

S Horinouchi - Current opinion in chemical biology, 2009 - Elsevier
Combinatorial biosynthesis includes an approach in which genes from different organisms
are assembled to design and construct an artificial gene cluster for production of bioactive …

Current and emerging approaches for natural product biosynthesis in microbial cells

KT Watts, BN Mijts… - Advanced Synthesis & …, 2005 - Wiley Online Library
Microorganisms and plants synthesize a tremendous diversity of chemical compounds. For
centuries, these compounds have been used as medicines, foods and other useful …

Metabolic engineering of Escherichia coli for natural product biosynthesis

D Yang, SY Park, YS Park, H Eun, SY Lee - Trends in Biotechnology, 2020 - cell.com
Natural products are widely employed in our daily lives as food additives, pharmaceuticals,
nutraceuticals, and cosmetic ingredients, among others. However, their supply has often …

Improvement of catechin production in Escherichia coli through combinatorial metabolic engineering

S Zhao, JA Jones, DM Lachance, N Bhan, O Khalidi… - Metabolic …, 2015 - Elsevier
Reconstruction of highly efficient biosynthesis pathways is essential for the production of
valuable plant secondary metabolites in recombinant microorganisms. In order to improve …