Calcium-permeable pores formed by small oligomers of amyloid proteins are the primary
pathologic species in Alzheimer's and Parkinson's diseases. However, the molecular …

A major characteristic of Alzheimer's disease (AD) is the presence of amyloid-β peptide (Aβ)
oligomers and aggregates in the brain. It is known that Aβ oligomers interact with the …

Brain cholesterol plays a critical role in Alzheimer's disease and other neurodegenerative
diseases. The molecular mechanisms linking cholesterol to neurotoxicity have remained …

The formation of amyloid-β peptide (Aβ) oligomers at the cellular membrane is considered to
be a crucial process underlying neurotoxicity in Alzheimer's disease (AD). Therefore, it is …

Oligomerization, conformational changes, and the consequent neurodegeneration of
Alzheimer′ s β‐amyloid protein (AβP) play crucial roles in the pathogenesis of Alzheimer …

The amyloid β (Aβ) peptide and its shorter variants, including a highly cytotoxic Aβ25–35
peptide, exert their neurotoxic effect during Alzheimer's disease by various mechanisms …

Alzheimer's disease is characterized by the aggregation and deposition of the Aβ peptide.
This 40 or 42 residue peptide is the product of the proteolysis of the amyloid precursor …

The 40 and 42 residue amyloid-β (Aβ) peptides are major components of the proteinaceous
plaques prevalent in the Alzheimer's disease-afflicted brain and have been shown to have …

Alzheimer disease is a progressive neurodegenerative brain disorder that leads to major
debilitating cognitive deficits. It is believed that the alterations capable of causing brain …

A central hallmark of Alzheimer's disease is the presence of extracellular amyloid plaques
chiefly consisting of amyloid-β (Aβ) peptides in the brain interstitium. Aβ largely exists in two …