The nematode worm Caenorhabditis elegans is a model system for the study of the genetic
basis of aging. Maternal-effect mutations in four genes—clk-1, clk-2, clk-3, and gro-1 …

A mutation in the age-1 gene of the nematode Caenorhabditis elegans has been shown to
result in a 65 percent increase in mean life-span and a 110 percent increase in maximum …

Mutations in the Caenorhabditis elegans genes lin-14, lin-28, and lin-29 cause
heterochronic developmental defects: the timing of specific developmental events in several …

The germ line of the nematode Caenorhabditis elegans influences life-span; when the germ-
line precursor cells are removed, life-span is increased dramatically. We find that neither …

The aging process has been dissected by analysis of genetic variants of the nematode
Caenorhabditis elegans. Long-lived recombinant inbred lines were generated; some of …

The Caenorhabditis elegans heterochronic genes control the relative timing and sequence
of many events during postembryonic development, including the terminal differentiation of …

Age-specific mortality rates in isogenic populations of the nematode Caenorhabditis elegans
increase exponentially throughout life. In genetically heterogeneous populations, age …

In their Perspective, Lithgow and Kirkwood postulate that evolutionary theory predicts that
the process of aging is not subject to selection in the same way as other physiological …

Crosses between Bristol and Bergerac strains of the self-fertilizing hermaphroditic nematode
Caenorhabditis elegans do not show the heterosis effects for life-span that complicate …

The free-living nematode Caenorhabditis elegans is used as a genetically manipulable
experimental system for the study of aging. Utilizing a temperature-sensitive sterile strain …