Abstract Background The role of Numb, a protein that is important for cell fate and
development and that, in human muscle, is expressed at reduced levels with advanced age …

Here, we investigated the mechanisms by which aging-related reductions of the levels of
Numb in skeletal muscle fibers contribute to loss of muscle strength and power, two critical …

Regeneration relies on coordinated action of multiple cell types to reconstitute the damaged
tissue. Here we inactivate the endocytic adaptor protein Numb in skeletal muscle stem cells …

Nandrolone, an anabolic steroid, slows denervation atrophy of rat muscle, prevents
denervation‐induced nuclear accumulation of intracellular domain of the Notch receptor …

A sarcomere is the contractile unit of the myofibril in striated muscles such as cardiac and
skeletal muscles. The assembly of sarcomeres depends on multiple molecules that serve as …

The adaptor protein Numb has been implicated in the switch between cell proliferation and
differentiation made by satellite cells during muscle repair. Using two genetic approaches to …

We previously identified four functionally distinct human NUMB isoforms. Here, we report the
identification of two additional isoforms and propose a link between the expression of these …

Numb has been shown to play diverse roles in the central nervous system of adult
mammals, and accumulating evidence indicates a role for Numb in apoptosis. In this study …

Mammalian Numb (mNumb) has multiple functions and plays important roles in the
regulation of neural development, including maintenance of neural progenitor cells and …

Numb carries the distinction of being the first molecule discovered to influence cell fate by
being asymmetrically segregated during cell division. Originally identified from studies in …