Background The study aimed to determine the efficacy of melatonin supplementation for
sleep disturbances in patients with traumatic brain injury (TBI). Methods This is a …

Primary objective: Whilst there is data to support the use of Melatonin in treating disorders of
the sleep–wake cycle, so far there is little published evidence on the efficacy of Melatonin in …

Traumatic brain injury (TBI) is common; however, effective treatments of the secondary brain
injury are scarce. Melatonin is a potent, nonselective neuroprotective and anti-inflammatory …

Background: Sleep-wake disturbances are highly prevalent following traumatic brain injury
(TBI), impeding rehabilitaion and quality of life. However, the mechanisms underlying these …

Sleep disturbances are commonly reported in children with persistent post-concussion
symptoms (PPCS). Melatonin treatment is often recommended, yet supporting evidence is …

Abstract Background The Present study was conducted to systematically review the effect of
the melatonin on sleep quality. We summarized evidence from randomized clinical trials …

Melatonin is an endogenous hormone mainly produced by the pineal gland whose
dysfunction leads to abnormal sleeping patterns. Changes in melatonin have been reported …

Melatonin (MEL) is a hormone that is produced in the brain and is known to bind to MEL-
specific receptors on neuronal membranes in several brain regions. MEL's documented …

A vast literature extolling the benefits of melatonin has accumulated during the past four
decades. Melatonin was previously considered of importance to seasonal reproduction and …

Primary objective: To investigate the circadian rhythm of serum melatonin in patients with
traumatic brain injury (TBI) during Intensive Care Unit (ICU) stay and its relationship with …