A Predominantly Clonal Multi-Institutional Outbreak of Clostridium difficile–Associated Diarrhea with High Morbidity and Mortality

VG Loo, L Poirier, MA Miller, M Oughton… - … England Journal of …, 2005 - Mass Medical Soc
Background In March 2003, several hospitals in Quebec, Canada, noted a marked increase
in the incidence of Clostridium difficile–associated diarrhea. Methods In 2004 we conducted …

Clinical features of clostridium difficile–associated infections and molecular characterization of strains: results of a retrospective study, 2000-2004

F Barbut, B Gariazzo, L Bonné, V Lalande… - Infection Control & …, 2007 - cambridge.org
Background. Recent outbreaks of severe cases of Clostridium difficile-associated diarrhea
(CDAD) reported in North America, the United Kingdom, and The Netherlands have …

Clinical and molecular epidemiology of sporadic and clustered cases of nosocomial Clostridium difficile diarrhea

MH Samore, L Venkataraman, PC DeGirolami… - The American journal of …, 1996 - Elsevier
purpose: A prospective clinical and molecular epidemiologic study was conducted to define
the frequency of nosocomial Clostridium difficile patient-to-patient transmission in an urban …

Emergence and control of fluoroquinolone-resistant, toxin A–negative, toxin B–positive Clostridium difficile

D Drudy, N Harnedy, S Fanning, M Hannan… - Infection Control & …, 2007 - cambridge.org
Background. Clostridium difficile is a major cause of infectious diarrhea in hospitalized
patients. Between August 2003 and January 2004, we experienced an increase in the …

Characterization of a Toxin A-Negative, Toxin B-Positive Strain of Clostridium difficile Responsible for a Nosocomial Outbreak of Clostridium difficile-Associated …

MJ Alfa, A Kabani, D Lyerly, S Moncrief… - Journal of clinical …, 2000 - Am Soc Microbiol
Clostridium difficile-associated diarrhea (CAD) is a very common nosocomial infection that
contributes significantly to patient morbidity and mortality as well as to the cost of …

Epidemiology, clinical manifestations, and outcome of Clostridium difficile-associated diarrhea.

A Anand, B Bashey, T Mir… - American Journal of …, 1994 - search.ebscohost.com
Objective: Clostridium difficile gastrointestinal disease is an important nosocomial infection
and is associated with recent antibiotic use. This study evaluated C. difficile-associated …

Risk factors for the development of Clostridium difficile-associated diarrhea during a hospital outbreak

A Thibault, MA Miller, C Gaese - Infection Control & Hospital …, 1991 - cambridge.org
Objective: To evaluate the risk factors associated with a nosocomial outbreak of Clostridium
difficile-associated diarrhea. Design: Case-control study with two control groups. Setting …

An Epidemic, Toxin Gene–Variant Strain of Clostridium difficile

LC McDonald, GE Killgore, A Thompson… - … England Journal of …, 2005 - Mass Medical Soc
Background Recent reports suggest that the rate and severity of Clostridium difficile–
associated disease in the United States are increasing and that the increase may be …

Morbidity, mortality, and healthcare burden of nosocomial Clostridium difficile-associated diarrhea in Canadian hospitals

MA Miller, M Hyland, M Ofner-Agostini… - Infection Control & …, 2002 - cambridge.org
Objective: To assess the healthcare burden, morbidity, and mortality of nosocomial
Clostridium difficile-associated diarrhea (N-CDAD) in Canadian hospitals. Design …

Nosocomial Outbreak of Clostridium difficile-Associated Diarrhoea due to a Clindamycin-Resistant Enterotoxin A-Negative Strain

E Kuijper, J Weerdt, H Kato, N Kato, A Dam… - European Journal of …, 2001 - Springer
A clindamycin-resistant toxin A-negative, toxin B-positive Clostridium difficile strain caused
an outbreak among 24 hospitalized patients at the Department of Surgery, the Intensive …