Pseudouridine in RNA: Enzymatic Synthesis Mechanisms and Functional Roles in Molecular Biology

A Khan, YD Hu, S Khan, SM Aqeel… - International …, 2023 - i.agriculturejournals.org
Pseudouridine, a common modified nucleotide, is prevalent in bacterial tRNA, rRNA, and
snRNA. Initially identified in rRNA and tRNA, its presence extends to snRNA. Despite being …

[图书][B] Investigation of the Roles of Pseudouridine Synthases in Ribosome Biogenesis and Epitranscriptomic Gene Regulation

K Jayalath - 2021 - search.proquest.com
Ribonucleotide modifications are ubiquitous in RNAs, including various types of non-coding
RNAs and messenger RNA (mRNA). Pseudouridine (?) is the most abundant single …

Pseudouridine site assignment by high-throughput in vitro RNA pseudouridylation and sequencing

NM Martinez, C Schaening-Burgos, WV Gilbert - Methods in enzymology, 2021 - Elsevier
Pseudouridine (Ψ) is one of the most abundant modifications in cellular RNAs. High-
throughput pseudouridine profiling of eukaryotic mRNAs from cells has revealed novel sites …

Regulation and function of RNA pseudouridylation in human cells

EK Borchardt, NM Martinez… - Annual review of …, 2020 - annualreviews.org
Recent advances in pseudouridine detection reveal a complex pseudouridine landscape
that includes messenger RNA and diverse classes of noncoding RNA in human cells. The …

Pseudouridine: the fifth RNA nucleotide with renewed interests

X Li, S Ma, C Yi - Current Opinion in Chemical Biology, 2016 - Elsevier
Highlights•Ψ is overall the most abundant RNA modification.•Ψ is wide-spread in ncRNAs
and plays important roles for their functions.•Ψ can be induced upon stress …

Investigating pseudouridylation mechanisms by high-throughput in vitro RNA pseudouridylation and sequencing

NM Martinez, WV Gilbert - RNA Modifications: Methods and Protocols, 2021 - Springer
Pseudouridine profiling has revealed many previously unknown sites of the RNA
modification pseudouridine (Ψ) in cellular RNAs. All organisms express multiple …

Incorporation of Pseudouridine into RNA for Biochemical and Biophysical Studies

T Sanford, A Riley, M Clawson, K Raasch… - RNA Structure and …, 2023 - Springer
Modification of RNA molecules has a significant effect on their structure and function. Many
different examples of RNA modifications have been observed and each contributes in …

[HTML][HTML] Insight into the mechanisms and functions of spliceosomal snRNA pseudouridylation

H Adachi, YT Yu - World Journal of Biological Chemistry, 2014 - ncbi.nlm.nih.gov
Pseudouridines (Ψs) are the most abundant and highly conserved modified nucleotides
found in various stable RNAs of all organisms. Most Ψs are clustered in regions that are …

[PDF][PDF] Pseudouridine in RNA: what, where, how, and why

M Charette, MW Gray - IUBMB life, 2000 - bpg.utoledo.edu
Summary Pseudouridine (5-ribosyluracil) is a ubiquitous yet enigmatic constituent of
structural RNAs (transfer, ribosomal, small nuclear, and small nucleolar). Although …

mRNA structure determines modification by pseudouridine synthase 1

TM Carlile, NM Martinez, C Schaening, A Su… - Nature chemical …, 2019 - nature.com
Pseudouridine (Ψ) is a post-transcriptional RNA modification that alters RNA–RNA and RNA–
protein interactions that affect gene expression. Messenger RNA pseudouridylation was …