Preliminary indications that the Attachment and Biobehavioral Catch-up Intervention alters DNA methylation in maltreated children

JR Hoye, D Cheishvili, HA Yarger, TL Roth… - Development and …, 2020 - cambridge.org
Maltreatment during development is associated with epigenetic changes to the genome.
Enhancing caregiving may mitigate these effects. Attachment and Biobehavioral Catch-Up …

[HTML][HTML] Childhood maltreatment and DNA methylation: A systematic review

CAM Cecil, Y Zhang, T Nolte - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
DNA methylation (DNAm)–an epigenetic process that regulates gene expression–may
represent a mechanism for the biological embedding of early traumatic experiences …

[HTML][HTML] DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up

KJ O'Donnell, L Chen, JL MacIsaac… - Translational …, 2018 - nature.com
This study reveals the influence of child maltreatment on DNA methylation across the
genome and provides the first evidence that a psychosocial intervention program, the Nurse …

Childhood maltreatment and DNA methylation: a systematic review

M Rubens, D Bruenig, JAM Adams, SM Suresh… - Neuroscience & …, 2023 - Elsevier
Child maltreatment (CM) encompasses sexual abuse, physical abuse, emotional abuse,
neglect, and exposure to domestic and family violence. Epigenetic research investigating …

DNA methylation and childhood maltreatment: from animal models to human studies

PE Lutz, G Turecki - Neuroscience, 2014 - Elsevier
Childhood maltreatment (CM) has estimated prevalence among Western societies between
10% and 15%. As CM associates with increased risk of several psychiatric disorders, early …

When mummy and daddy get under your skin: A new look at how parenting affects children's DNA methylation, stress reactivity, and disruptive behavior

G Overbeek, N Creasey, C Wesarg… - New directions for …, 2020 - Wiley Online Library
Child maltreatment is a global phenomenon that affects the lives of millions of children.
Worldwide, as many as one in three to six children encounter physical, sexual, or emotional …

Differential patterns of whole-genome DNA methylation in institutionalized children and children raised by their biological parents

OY Naumova, M Lee, R Koposov, M Szyf… - Development and …, 2012 - cambridge.org
Previous studies with nonhuman species have shown that animals exposed to early
adversity show differential DNA methylation relative to comparison animals. The current …

An investigation of child maltreatment and epigenetic mechanisms of mental and physical health risk

D Cicchetti, S Hetzel, FA Rogosch… - Development and …, 2016 - cambridge.org
In the present investigation, differential methylation analyses of the whole genome were
conducted among a sample of 548 school-aged low-income children (47.8% female, 67.7 …

[HTML][HTML] A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches

SH Parade, L Huffhines, TE Daniels, LR Stroud… - Translational …, 2021 - nature.com
Childhood maltreatment is a major risk factor for chronic and severe mental and physical
health problems across the lifespan. Increasing evidence supports the hypothesis that …

Global and gene-specific DNA methylation alterations in the adolescent amygdala and hippocampus in an animal model of caregiver maltreatment

TS Doherty, A Forster, TL Roth - Behavioural brain research, 2016 - Elsevier
Epigenetic mechanisms such as DNA methylation are part of an emerging story on how
early-life experiences can alter behavioral trajectories and lead to the development of …