Changes in antidepressant use by young people and suicidal behavior after FDA warnings and media coverage: quasi-experimental study

CY Lu, F Zhang, MD Lakoma, JM Madden, D Rusinak… - Bmj, 2014 - bmj.com
Objective To investigate if the widely publicized warnings in 2003 from the US Food and
Drug Administration about a possible increased risk of suicidality with antidepressant use in …

Antidepressants and suicide risk: how did specific information in FDA safety warnings affect treatment patterns?

SH Busch, RG Frank, DL Leslie, A Martin… - Psychiatric …, 2010 - Am Psychiatric Assoc
Drug Administration (FDA) released five safety warnings related to antidepressant use and
the increased risk of suicidality for children. Although researchers have documented a …

Effect of regulatory warnings on antidepressant prescription rates, use of health services and outcomes among children, adolescents and young adults

LY Katz, AL Kozyrskyj, HJ Prior, MW Enns, BJ Cox… - Cmaj, 2008 - Can Med Assoc
Background: Regulatory bodies worldwide, including Health Canada, have issued warnings
about prescribing antidepressants to children and adolescents. We sought to determine …

Antidepressants and suicide: what is the balance of benefit and harm

D Gunnell, D Ashby - Bmj, 2004 - bmj.com
Prescribing of antidepressants has increased greatly in England and elsewhere in recent
years. 1–3 This increase has coincided with a fall in rates of suicide, leading some …

Antidepressants and the risk of suicide in young persons–prescription trends and toxicological analyses

G Isacsson, J Ahlner - Acta psychiatrica scandinavica, 2014 - Wiley Online Library
Objective To assess trends in the use of antidepressants among young suicides after the
warning that these drugs might increase the risk of suicide. Method Individual data of all 845 …

Antidepressant use and risk of suicide and attempted suicide or self harm in people aged 20 to 64: cohort study using a primary care database

C Coupland, T Hill, R Morriss, A Arthur, M Moore… - bmj, 2015 - bmj.com
Objective To assess the associations between different antidepressant treatments and the
rates of suicide and attempted suicide or self harm in people with depression. Design Cohort …

Funding for primary health care in developing countries

J De Maeseneer, C Van Weel, D Egilman, K Mfenyana… - BMJ, 2008 - bmj.com
Two accompanying observational studies by Biddle and colleagues and Wheeler and
colleagues add to the recent literature regarding changes in antidepressant use and …

Risk of suicidality in clinical trials of antidepressants in adults: analysis of proprietary data submitted to US Food and Drug Administration

M Stone, T Laughren, ML Jones, M Levenson… - Bmj, 2009 - bmj.com
Objective To examine the risk of suicidal behaviour within clinical trials of antidepressants in
adults. Design Meta-analysis of 372 double blind randomised placebo controlled trials …

[HTML][HTML] Duty to warn: antidepressant black box suicidality warning is empirically justified

GI Spielmans, T Spence-Sing, P Parry - Frontiers in psychiatry, 2020 - frontiersin.org
The United States Food and Drug Administration issued a Black Box warning in October
2004 after placebo-controlled trials of antidepressant medications found an increased risk of …

Antidepressants and suicide

SS Jick, AD Dean, H Jick - Bmj, 1995 - bmj.com
Objective: To estimate the rate and means of suicide among people taking 10 commonly
prescribed antidepressant drugs: dothiepin, amitriptyline, clomipramine, imipramine …