Cardiac metabolic alterations in hypertensive obese pigs
Obesity and hypertension are major risk factors for cardiovascular diseases, and their
growing coexistence accounts for an increase in adverse cardiac events, but the …
growing coexistence accounts for an increase in adverse cardiac events, but the …
The high-fat diet induces myocardial fibrosis in the metabolically healthy obese minipigs—The role of ER stress and oxidative stress
SJ Li, CH Liu, HP Chu, HJ Mersmann, ST Ding… - Clinical Nutrition, 2017 - Elsevier
Background The cellular mechanisms of obesity-induced cardiomyopathy are multiple and
not completely elucidated. The objective of this study was to differentiate two obesity …
not completely elucidated. The objective of this study was to differentiate two obesity …
Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity
S Boudina, S Sena, BT O'Neill, P Tathireddy… - Circulation, 2005 - Am Heart Assoc
Background—Obesity is a risk factor for cardiovascular disease and is strongly associated
with insulin resistance and type 2 diabetes. Recent studies in obese humans and animals …
with insulin resistance and type 2 diabetes. Recent studies in obese humans and animals …
Compromised mitochondrial remodeling in compensatory hypertrophied myocardium of spontaneously hypertensive rat
Y Tang, C Mi, J Liu, F Gao, J Long - Cardiovascular Pathology, 2014 - Elsevier
Background Hypertension leads to cardiac hypertrophy as an adaptive response to
increased workload. While initial development of hypertrophy is compensatory when …
increased workload. While initial development of hypertrophy is compensatory when …
Transition from obesity to metabolic syndrome is associated with altered myocardial autophagy and apoptosis
ZL Li, JR Woollard, B Ebrahimi, JA Crane… - … , and vascular biology, 2012 - Am Heart Assoc
Objective—Transition from obesity to metabolic-syndrome (MetS) promotes cardiovascular
diseases, but the underlying cardiac pathophysiological mechanisms are incompletely …
diseases, but the underlying cardiac pathophysiological mechanisms are incompletely …
Renovascular hypertension induces myocardial mitochondrial damage, contributing to cardiac injury and dysfunction in pigs with metabolic syndrome
AA Nargesi, MC Farah, XY Zhu, L Zhang… - American journal of …, 2021 - academic.oup.com
BACKGROUND Renovascular hypertension (RVH) often manifest with metabolic syndrome
(MetS) as well. Coexisting MetS and hypertension increases cardiovascular morbidity and …
(MetS) as well. Coexisting MetS and hypertension increases cardiovascular morbidity and …
Obesity-metabolic derangement exacerbates cardiomyocyte loss distal to moderate coronary artery stenosis in pigs without affecting global cardiac function
Obesity associated with metabolic derangements (ObM) worsens the prognosis of patients
with coronary artery stenosis (CAS), but the underlying cardiac pathophysiologic …
with coronary artery stenosis (CAS), but the underlying cardiac pathophysiologic …
A high-fat diet increases adiposity but maintains mitochondrial oxidative enzymes without affecting development of heart failure with pressure overload
DJ Chess, RJ Khairallah, KM O'Shea… - American Journal …, 2009 - journals.physiology.org
A high-fat diet can increase adiposity, leptin secretion, and plasma fatty acid concentration.
In hypertension, this scenario may accelerate cardiac hypertrophy and development of heart …
In hypertension, this scenario may accelerate cardiac hypertrophy and development of heart …
A high‐fat diet impairs mitochondrial biogenesis, mitochondrial dynamics, and the respiratory chain complex in rat myocardial tissues
D Chen, X Li, LT Zhang, M Zhu… - Journal of cellular …, 2018 - Wiley Online Library
A high‐fat diet (HFD) has been associated with heart failure and arrhythmias; however, the
molecular mechanisms underlying these associations are poorly understood. The …
molecular mechanisms underlying these associations are poorly understood. The …
Impaired cardiac mitochondrial oxidative phosphorylation and enhanced mitochondrial oxidative stress in feline hypertrophic cardiomyopathy
LB Christiansen, F Dela, J Koch… - American Journal …, 2015 - journals.physiology.org
Mitochondrial dysfunction and oxidative stress are important players in the development of
various cardiovascular diseases, but their roles in hypertrophic cardiomyopathy (HCM) …
various cardiovascular diseases, but their roles in hypertrophic cardiomyopathy (HCM) …