Acetaminophen is a commonly used antipyretic and analgesic agent. It is safe when taken at
therapeutic doses; however, overdose can lead to serious and even fatal hepatotoxicity. The …

Acetaminophen-induced hepatotoxicity is a common consequence of acetaminophen
overdose and may lead to acute liver failure (ALF). Currently acetaminophen is the most …

Acetaminophen is a widely used nonprescription analgesic and antipyretic agent. It is also a
dose-related hepatotoxin that can cause fulminant liver failure when taken in massive …

Hepatic injury and subsequent hepatic failure due to both intentional and non-intentional
overdose of acetaminophen (APAP) has affected patients for decades, and involves the …

As the most common cause of acute liver failure (ALF) in the USA and UK, acetaminophen-
induced hepatotoxicity remains a significant public health concern and common indication …

A review of the typical clinical course, diagnosis and treatment of acetaminophen toxicity is
provided. For an acute overdose, most adults must ingest about 12 g or more …

Background & Aims: Five hundred sixty patients admitted between January 1, 1987, and
December 31, 1993, with severe acetaminophen-induced hepatotoxicity were studied. The …

Over the past five or more years, laboratory and clinical investigations aimed at elucidating
the pathogenesis of acetaminophen-induced liver-cell necrosis have achieved a striking …

Background: Acetaminophen overdose is a frequent cause of acute liver failure. Controversy
exists over the rare association of severe hepatotoxicity or acute liver failure with therapeutic …

Acetaminophen has been used safely and effectively for many years to manage pain and/or
fever in patients of all ages. It is commonly recommended as first-line therapy for a variety of …