Bi‐directional activation between mesenchymal stem cells and CLL B‐cells: implication for CLL disease progression
W Ding, GS Nowakowski, TR Knox… - British journal of …, 2009 - Wiley Online Library
It was hypothesized that contact between chronic lymphocytic leukaemia (CLL) B‐cells and
marrow stromal cells impact both cell types. To test this hypothesis, we utilized a long‐term …
marrow stromal cells impact both cell types. To test this hypothesis, we utilized a long‐term …
[HTML][HTML] Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survival
V Trimarco, E Ave, M Facco, G Chiodin, F Frezzato… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abstract Leukemic cells from Chronic Lymphocytic Leukemia (CLL) patients interact with
stromal cells of the surrounding microenvironment. Mesenchymal Stromal Cells (MSCs) …
stromal cells of the surrounding microenvironment. Mesenchymal Stromal Cells (MSCs) …
Chronic lymphocytic leukemia cells induce anti-apoptotic effects of bone marrow stroma
M Plander, P Ugocsai, S Seegers, E Orsó… - Annals of …, 2011 - Springer
The prolonged life span of chronic lymphocytic leukemia (CLL) cells in vivo is assumed to
depend on the surrounding microenvironment since this biologic feature is lost in vitro. We …
depend on the surrounding microenvironment since this biologic feature is lost in vitro. We …
[HTML][HTML] Co-culture of primary CLL cells with bone marrow mesenchymal cells, CD40 ligand and CpG ODN promotes proliferation of chemoresistant CLL cells …
N Purroy, P Abrisqueta, J Carabia, C Carpio… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Chronic lymphocytic leukemia (CLL) cells residing in the bone marrow (BM) and in
secondary lymphoid tissues receive survival and proliferative signals from the …
secondary lymphoid tissues receive survival and proliferative signals from the …
Bone marrow stromal mesenchymal cells induce down regulation of CD 20 expression on B‐CLL: implications for rituximab resistance in CLL
ME Marquez, O Hernández‐Uzcátegui… - British journal of …, 2015 - Wiley Online Library
Although the majority of B cells express surface CD 20 in chronic lymphocytic leukaemia (B‐
CLL), only∼ 50% of patients respond to treatment with rituximab. Decreased CD 20 …
CLL), only∼ 50% of patients respond to treatment with rituximab. Decreased CD 20 …
Study of the quantitative, functional, cytogenetic, and immunoregulatory properties of bone marrow mesenchymal stem cells in patients with B-cell chronic lymphocytic …
C Pontikoglou, MC Kastrinaki, M Klaus… - Stem cells and …, 2013 - liebertpub.com
The bone marrow (BM) microenvironment has clearly been implicated in the pathogenesis
of B-cell chronic lymphocytic leukemia (B-CLL). However, the potential involvement of BM …
of B-cell chronic lymphocytic leukemia (B-CLL). However, the potential involvement of BM …
Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro
P Panayiotidis, D Jones, K Ganeshaguru… - British journal of …, 1996 - Wiley Online Library
Leukaemic cells from most cases of B‐chronic lymphocytic leukaemia die rapidly by
apoptosis in vitro unless they are cultured in the presence of interleukin‐4 or interferon α or …
apoptosis in vitro unless they are cultured in the presence of interleukin‐4 or interferon α or …
Impact of bone marrow stromal cells on Bcl-2 family members in chronic lymphocytic leukemia
V Patel, LS Chen, WG Wierda… - Leukemia & …, 2014 - Taylor & Francis
Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia in the
Western world. High levels of Bcl-2 family anti-apoptotic proteins are responsible for …
Western world. High levels of Bcl-2 family anti-apoptotic proteins are responsible for …
Interactions between bone marrow stromal microenvironment and B-chronic lymphocytic leukemia cells: any role for Notch, Wnt and Hh signaling pathways?
PFS Etet, L Vecchio, AHN Kamdje - Cellular signalling, 2012 - Elsevier
B-cell chronic lymphocytic leukemia (CLL), which is the most common lymphoproliferative
disorder, displays characteristics consistent with a defect in programmed cell death and …
disorder, displays characteristics consistent with a defect in programmed cell death and …
Differential bone marrow homing capacity of VLA-4 and CD38 high expressing chronic lymphocytic leukemia cells
G Brachtl, K Sahakyan, U Denk, T Girbl, B Alinger… - PLoS …, 2011 - journals.plos.org
Background VLA-4 and CD38 predict a poor clinical outcome in chronic lymphocytic
leukemia (CLL). We used CLL samples with discordant VLA-4/CD38 risk to address their …
leukemia (CLL). We used CLL samples with discordant VLA-4/CD38 risk to address their …