The molecular evolution of the interleukin-1 family of cytokines; IL-18 in teleost fish
MO Huising, RJM Stet, HFJ Savelkoul… - Developmental & …, 2004 - Elsevier
The cytokine network is an important homeostatic system with potent activities in immune
surveillance, growth, developmental and repair processes. Although interleukin-1β (IL-1β) is …
surveillance, growth, developmental and repair processes. Although interleukin-1β (IL-1β) is …
An unexpected discovery of two interferon gamma-like genes along with interleukin (IL)-22 and-26 from teleost: IL-22 and-26 genes have been described for the first …
By comparative genomics based on chromosome synteny between human and fish, IL-22, IL-
26 and two IFN-γ-like genes have been isolated in fish. Interleukin-22 and-26 have been …
26 and two IFN-γ-like genes have been isolated in fish. Interleukin-22 and-26 have been …
Two interleukin (IL)-15 homologues in fish from two distinct origins
Here, we report two distinct genes in teleosts that are homologous to interleukin (IL)-15. The
two genes, isolated from fugu (Takifugu rubripes), resemble to mammalian IL-15 but differ …
two genes, isolated from fugu (Takifugu rubripes), resemble to mammalian IL-15 but differ …
The interleukins of fish
Interleukins are a subgroup of cytokines, molecules involved in the intercellular regulation of
the immune system. The term interleukin was first coined in 1979 to refer to molecules that …
the immune system. The term interleukin was first coined in 1979 to refer to molecules that …
Characterisation, expression and ontogeny of interleukin-6 and its receptors in zebrafish (Danio rerio)
Interleukin-6 (IL-6) is one of the most pleiotropic cytokines due to its importance in both
innate and adaptive immune responses and other physiological processes. In this study, we …
innate and adaptive immune responses and other physiological processes. In this study, we …
Characterisation and expression analysis of an interleukin 6 homologue in the Japanese pufferfish, Fugu rubripes
The first IL-6 sequence in fish has been determined in Fugu rubripes by exploiting the
synteny that is found between some regions of the human and Fugu genomes. The …
synteny that is found between some regions of the human and Fugu genomes. The …
Evolution of the interleukins
P Kaiser, L Rothwell, S Avery, S Balu - Developmental & Comparative …, 2004 - Elsevier
As the adaptive immune system arose in jawed vertebrates, a reasonable working
hypothesis is that cytokines involved exclusively in controlling the adaptive immune system …
hypothesis is that cytokines involved exclusively in controlling the adaptive immune system …
The IL-12 family cytokines in fish: Molecular structure, expression profile and function
X Wang, A Zhang, X Qiu, K Yang, H Zhou - Developmental & Comparative …, 2023 - Elsevier
Abstract Interleukin (IL)-12 family cytokines including IL-12, IL-23, IL-27, IL-35 and IL-39 are
heterodimeric cytokines composed of two subunits, an α-chain (entitled p35, p19 and p28) …
heterodimeric cytokines composed of two subunits, an α-chain (entitled p35, p19 and p28) …
Characterisation and expression analysis of interleukin 2 (IL-2) and IL-21 homologues in the Japanese pufferfish, Fugu rubripes, following their discovery by synteny
This investigation provides the first conclusive evidence for the existence of the interleukin 2
(IL-2) and IL-21 genes in bony fish. The IL-2 and IL-21 sequences have been determined in …
(IL-2) and IL-21 genes in bony fish. The IL-2 and IL-21 sequences have been determined in …
Characterisation, expression and promoter analysis of an interleukin 10 homologue in the puffer fish, Fugu rubripes
Using computer-based tools, an interleukin (IL) 10 homologue has been identified from the
puffer fish (Fugu rubripes) genome database. This is the first report on the existence of an IL …
puffer fish (Fugu rubripes) genome database. This is the first report on the existence of an IL …