Background—Heme oxygenase (HO)-1 is an enzyme that degrades heme to generate CO
(a vasodilatory gas), iron, and the potent antioxidant bilirubin. A disease process …

Heme oxygenase (HO) is a cytoprotective enzyme that degrades heme (a potent oxidant) to
generate carbon monoxide (a vasodilatory gas that has anti-inflammatory properties) …

抄録 Hemorrhagic shock causes oxidative stress that leads to tissue injuries in various
organs including the lung, liver, kidney and intestine. Excess amounts of free heme released …

Heme oxygenase (HO) 1 is inducible by a variety of oxidative stress and is thought to play
an important role in the protection of tissues from oxidative injuries. Because hemorrhagic …

Oxidant-mediated reperfusion injury of the gut is a major contributor of the systemic
inflammatory response in hemorrhagic shock. Recent studies have suggested that heme …

Heme oxygenase-1 may exert cytoprotective effects. In this study we examined the
sensitivity of heme oxygenase-1 knockout (HO-1−/−) mice to renal ischemia by assessing …

Heme oxygenase (HO) is a cytoprotective enzyme that degrades heme (a potent oxidant) to
generate carbon monoxide (a vasodilatory gas that has anti-inflammatory properties) …

Heme oxygenase (HO) represents an intrinsic anti-inflammatory system based on its ability
to regulate leukocyte function and inhibit expression of proinflammatory cytokines. This anti …

Heme oxygenase (HO)-1 generates CO, a gas with vasodilatory properties, during heme
metabolism. HO-1 is expressed highly in vascular tissue after endotoxin stimulation, and …

Background: Heme-oxygenase (HO)-1 acts as an inducible defense against oxidative stress
and could play an important role in inflammation models, providing protection against …