Although a large body of evidence has shown that peripheral nerve injury usually induces
neuropathic pain, there are also clinical studies demonstrating that injury of the sural nerve …

Pain usually arises as a consequence of activation of primary nociceptive afferences by
tissue-damaging stimuli. Sometimes pain comes from the nervous system and can persist for …

The NMDA receptor and the brain-derived neurotrophic factor (BDNF) are involved in central
sensitization and synaptic plasticity in the spinal cord. To determine whether the spinal cord …

Brain-derived neurotrophic factor (BDNF) is involved in neuronal survival and synaptic
plasticity of the central and peripheral nervous system. In chronic pain, plastic changes in …

Nociceptive nerves innervate the skin and play an important role in the generation of
neuropathic pain. However, it remains elusive whether and how nociceptive nerve terminals …

Chronic constriction injury of the sciatic nerve and lumbar L5 and L6 spinal nerve ligation
provide animal models for pain syndromes accompanying peripheral nerve injury and …

Background Cuff and spared nerve injury (SNI) in the sciatic territory are widely used to
model neuropathic pain. Because nociceptive information is first detected in skin, it is …

Chronic pain after nerve injury is often accompanied by hypersensitivity to mechanical
stimuli, yet whether this reflects altered input, altered processing, or both remains unclear …

Selective motor nerve injury by lumbar 5 ventral root transection (L5 VRT) induces
neuropathic pain, but the underlying mechanisms remain unknown. Previously, increased …

It has been shown that following peripheral nerve injury brain-derived neurotrophic factor
(BDNF) released by activated microglia contributes to neuropathic pain, but whether BDNF …