Correlation of camptothecin-producing ability and phylogenetic relationship in the genus Ophiorrhiza

V Viraporn, M Yamazaki, K Saito… - Planta …, 2011 - thieme-connect.com
Camptothecin (CPT) is an essential precursor of semisynthetic chemotherapeutic agents for
cancers throughout the world. In spite of the rapid growth of market demand, CPT raw …

Divergent camptothecin biosynthetic pathway in Ophiorrhiza pumila

M Yang, Q Wang, Y Liu, X Hao, C Wang, Y Liang… - BMC biology, 2021 - Springer
Background The anticancer drug camptothecin (CPT), first isolated from Camptotheca
acuminata, was subsequently discovered in unrelated plants, including Ophiorrhiza pumila …

Ophiorrhiza, a promising herbaceous source of the anticancer compound camptothecin

G Krishnakumar, KP Dintu, SC Varghese… - Plant Science …, 2020 - horizonepublishing.com
Camptothecin is an important source for the synthesis of some of the major anti-cancer
agents such as irinotecan and topotecan. Traditional source of camptothecin are …

Biotechnology for micropropagation and camptothecin production in Ophiorrhiza sp.

DK Pandey, M Konjengbam, M Ghorai… - Applied Microbiology …, 2022 - Springer
Camptothecin (CPT) is a monoterpenoid-alkaloid, an anticancer compound from plant. Ever
since its discovery in 1996 from the bark of Camptotheca acuminata, various researches …

Biotechnology of camptothecin production in Nothapodytes nimmoniana, Ophiorrhiza sp. and Camptotheca acuminata

MK Swamy, S Nath, S Paul, NK Jha… - Applied Microbiology …, 2021 - Springer
Cancer is probably the deadliest human disease in recent years. In the past few years, rapid
clinical progress has been made in the field of anticancer drug development. Plant …

Search for camptothecin-yielding Ophiorrhiza species from southern Western Ghats in India: a HPTLC-densitometry study

R Rajan, SC Varghese, R Kurup… - Industrial Crops and …, 2013 - Elsevier
Camptothecin (CPT) content in 44 accessions belonging to nine Ophiorrhiza species and
three varieties collected from their natural habitats in the Kerala region of Western Ghats …

Camptothecin production by in vitro cultures of Ophiorrhiza liukiuensis and O. kuroiwai

T Asano, I Watase, H Sudo, M KITAJIMA… - Plant …, 2004 - jstage.jst.go.jp
Camptothecin derived compounds are widely used for clinical treatment of human cancer.
They are synthesized from natural camptothecin, which is obtained by extraction from intact …

Suppression of camptothecin biosynthetic genes results in metabolic modification of secondary products in hairy roots of Ophiorrhiza pumila

T Asano, K Kobayashi, E Kashihara, H Sudo, R Sasaki… - Phytochemistry, 2013 - Elsevier
Camptothecin is a monoterpenoid indole alkaloid that exhibits anti-tumor activity. In
Ophiorrhiza pumila, production of camptothecin and its related alkaloids was high in the …

HPTLC-based quantification of camptothecin in Ophiorrhiza species of the southern Western Ghats in India

R Rajan, SC Varghese, R Kurup… - Cogent …, 2016 - Taylor & Francis
Camptothecin (CPT), a modified monoterpene indole alkaloid, is a potential anticancer drug,
and due to high demand, search for its new plant-based sources is a priority. Genus …

Tissue culture studies and estimation of camptothecin from Ophiorrhiza prostrata D. Don

K Gopalakrishnan, S Krishnan… - Indian journal of plant …, 2018 - Springer
Camptothecin is an important molecule in the synthesis of some of major anticancer agents
such as irinotecan and topotecan. Traditional sources of camptothecin are mainly woody …