CD1 molecules are specialized in presenting lipids to T lymphocytes, but identification and
isolation of CD1-restricted lipidspecific T cells has been hampered by the lack of reliable …

CD1 proteins constitute a third class of antigen-presenting molecules. They bind lipids rather
than peptides, and the T cells reactive to lipids presented by CD1 have been implicated in …

Unlike the dominant role of one class II invariant chain peptide (CLIP) in blocking MHC class
II, comparative lipidomics analysis shows that human cluster of differentiation (CD) proteins …

CD1d is an MHC class I-like membrane glycoprotein that presents lipid Ags to NKT cells.
Despite intensive biochemical, genetic, and structural studies, the endogenous lipids …

Self‐glycosphingolipids bind to surface CD1 molecules and are readily displaced by other
CD1 ligands. This capacity to exchange antigens at the cell surface is not common to other …

Structural studies of CD1d presentation of α-galactosylceramide have shown that the lipid
component fits snugly in the cleft, whereas the galactosyl head group protrudes upward, with …

The CD1 family of major histocompatibility complex (MHC)-like molecules specializes in
presenting lipid and glycolipid antigens to α/β T lymphocytes, but little is known about the …

CD1e is the only human CD1 protein existing in soluble form in the late endosomes of
dendritic cells, where it facilitates the processing of glycolipid antigens that are ultimately …

It is now well demonstrated that the repertoire of T cells includes not only cells that recognize
specific MHC-presented peptide antigens, but also cells that recognize specific self and …

Five CD1 molecules are expressed in humans and it is unclear whether they have
specialized or redundant functions. We found that sulfatide is a promiscuous CD1-binding …