Hot melt extrusion (HME) is a powerful technology to enhance the solubility and
bioavailability of poorly water-soluble drugs by producing amorphous solid dispersions …

The use of hot-melt extrusion (HME) within the pharmaceutical industry is steadily
increasing, due to its proven ability to efficiently manufacture novel products. The process …

The solubility of the drug is a significant aspect to be considered during manufacturing of
pharmaceutical products. Poor aqueous solubility of drugs imparts depleted bioavailability …

Introduction: Hot-melt extrusion (HME) technology is applied successfully in the plastic,
rubber and food industry. HME has also emerged as an important technology for drug …

Over the last few decades, hot melt extrusion (HME) has emerged as a successful
technology for a broad spectrum of applications in the pharmaceutical industry. As indicated …

Hot-melt extrusion has found extensive application as a feasible pharmaceutical
technological option over recent years. HME applications include solubility enhancement …

This chapter appraises the role of melt extrusion as a solubilization and bioavailability
enhancement technique. The introductory chapter highlights major aspects of hot melt …

In today's pharmaceutical arena, it is estimated that more than 40% of new chemical entities
produced during drug discovery efforts exhibit poor solubility characteristics. However, over …

After decades of development, hot melt extrusion (HME) technology has matured as a well-
established pharmaceutical methodology. Through the process of extruding both drug and …

Abstract Hot Melt Extrusion (HME) technology is a widely used for manufacturing process in
the plastic and pharmaceutical industries and is an efficient and simple for the production of …