The hierarchical packaging of DNA into chromatin within a eukaryotic nucleus plays a
pivotal role in both the accessibility of genomic information and the dynamics of replication …

The architecture of the chromatin fiber, which determines DNA accessibility for transcription
and other template-directed biological processes, remains unknown. Here we investigate …

Chromatin conformation is dynamic and heterogeneous with respect to nucleosome
positions, which can be changed by chromatin remodeling complexes in the cell. These …

The dynamic organization of chromatin plays an essential role in the regulation of gene
expression and in other fundamental cellular processes. The underlying physical basis of …

The three-dimensional structure of chromatin affects DNA accessibility and is therefore a key
regulator of gene expression. However, the path of the DNA between consecutive …

Based on model structures with atomic resolution, a coarse-grained model for the
nucleosome geometry was implemented. The dependence of the chromatin fiber …

In addition to being the gateway for all access to the eukaryotic genome, chromatin has in
recent years been identified as carrying an epigenetic code regulating transcriptional …

Background: The compact form of the chromatin fiber is a critical regulator of fundamental
processes such as transcription and replication. These reactions can occur only when the …

Chromatin domains formed in vivo are characterized by different types of 3D organization of
interconnected nucleosomes and architectural proteins. Here, we quantitatively test a …

Within a living cell, the myriad of proteins that bind DNA introduce heterogeneously spaced
kinks into an otherwise semiflexible DNA double helix. To investigate the effects of …