As p53 and its homologue p73 have significant sequence and functional similarities, p73
might also be expected to act as a tumour suppressor. However, p73 is activated after DNA …

The recently identified p53 family member, p73, shows substantial structural and functional
homology with p53. However, despite the established role of p53 as a proto-type tumor …

p73 belongs to a family of p53‐related nuclear transcription factors that includes p53, p73
and p63. The overall structure and sequence homology indicates that a p63/p73‐like …

The TP53 tumour-suppressor gene belongs to a family that includes the two recently
identified homologues TP63 and TP73. Overexpression of p73 can activate typical p53 …

Abstract p73, a recently identified gene highly homologous to p53, can transactivate p53
target genes and induce apoptosis. Here we report the identification of an NH2-terminal …

The identification of upstream pathways that signal to TP73 is crucial for understanding the
biological role of this gene. Since some evidence suggests thatTP73 might play a role in …

The candidate tumor suppressor p73 has a high sequence homology with p53 within the
NH2-terminal transactivation domain, the sequence-specific DNA-binding region, and the …

p73, a p53 family protein, shares significant sequence homolog and functional similarity with
p53. However, unlike p53, p73 has at least seven alternatively spliced isoforms with different …

Abstract p73, a potential tumor suppressor, is a p53 homologue. Transient over expression
of p73 in cells can induce apoptosis and p21, a cellular p53 target gene primarily …

p53 is mutated in∼ 50% of human cancers, whereas mutations of the related p73 gene are
rare. p73 can activate p53-responsive promoters and induce apoptosis when overexpressed …