[HTML][HTML] Long-term continuous corticosterone treatment decreases VEGF receptor-2 expression in frontal cortex
KR Howell, A Kutiyanawalla, A Pillai - PloS one, 2011 - journals.plos.org
Objective Stress and increased glucocorticoid levels are associated with many
neuropsychiatric disorders including schizophrenia and depression. Recently, the role of …
neuropsychiatric disorders including schizophrenia and depression. Recently, the role of …
Decreased VEGFR2 expression and increased phosphorylated Akt1 in the prefrontal cortex of individuals with schizophrenia
M Hino, Y Kunii, J Matsumoto, A Wada… - Journal of psychiatric …, 2016 - Elsevier
The Akt signaling pathway involves various cellular processes and depends on extracellular
stimuli. Since Akt signaling participates in cytoprotection, synapse plasticity, axon extension …
stimuli. Since Akt signaling participates in cytoprotection, synapse plasticity, axon extension …
Stress-induced neuronal colony stimulating factor 1 provokes microglia-mediated neuronal remodeling and depressive-like behavior
Background Chronic stress exposure causes neuronal atrophy and synaptic deficits in the
medial prefrontal cortex (PFC), contributing to development of anxiety-and depressive-like …
medial prefrontal cortex (PFC), contributing to development of anxiety-and depressive-like …
VEGF regulates antidepressant effects of lamotrigine
R Sun, N Li, T Li - European Neuropsychopharmacology, 2012 - Elsevier
The anticonvulsant drug lamotrigine has been shown to produce strong antidepressant
effects in the treatment of bipolar disorder patients. Our previous studies have demonstrated …
effects in the treatment of bipolar disorder patients. Our previous studies have demonstrated …
[HTML][HTML] Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness
Molecular abnormalities within the glucocorticoid receptor (GR) stress signaling pathway
may confer, or reflect, susceptibility to stress in schizophrenia and bipolar disorder, but the …
may confer, or reflect, susceptibility to stress in schizophrenia and bipolar disorder, but the …
Effect of stress on prefrontal cortex function
B Moghaddam, M Jackson - Neurotoxicity Research, 2004 - Springer
Stress is the major epigenetic factor that contributes to the etiology, pathophysiology, and
treatment out-come of most psychiatric disorders. Understanding the mechanisms by which …
treatment out-come of most psychiatric disorders. Understanding the mechanisms by which …
Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress
MJ Horchar, ES Wohleb - Brain, behavior, and immunity, 2019 - Elsevier
Synaptic deficits and neuronal dystrophy in the prefrontal cortex (PFC) are linked to
behavioral and cognitive symptoms in depressed individuals. Preclinical studies indicate …
behavioral and cognitive symptoms in depressed individuals. Preclinical studies indicate …
[HTML][HTML] Glucocorticoid receptor and FKBP5 expression is altered following exposure to chronic stress: modulation by antidepressant treatment
G Guidotti, F Calabrese, C Anacker… - …, 2013 - nature.com
Major depression is thought to originate from the interaction between susceptibility genes
and adverse environmental events, in particular stress. The hypothalamus–pituitary–adrenal …
and adverse environmental events, in particular stress. The hypothalamus–pituitary–adrenal …
[HTML][HTML] Fluoxetine prevents development of an early stress-related molecular signature in the rat infralimbic medial prefrontal cortex. Implications for depression?
RA Barreto, FR Walker, PR Dunkley, TA Day… - BMC neuroscience, 2012 - Springer
Background Psychological stress, particularly in chronic form, can lead to mood and
cognitive dysfunction and is a major risk factor in the development of depressive states. How …
cognitive dysfunction and is a major risk factor in the development of depressive states. How …
VEGF-induced antidepressant effects involve modulation of norepinephrine and serotonin systems
H Udo, K Hamasu, M Furuse, H Sugiyama - Behavioural brain research, 2014 - Elsevier
Throughout life, we are exposed to a variety of stresses, which may be inevitable and
noxious sometimes. During evolution, animals must have acquired some physiological …
noxious sometimes. During evolution, animals must have acquired some physiological …