RNA abundance is a powerful indicator of the state of individual cells. Single-cell RNA
sequencing can reveal RNA abundance with high quantitative accuracy, sensitivity and …

Our understanding of human biology and disease is ultimately dependent on a complete
understanding of the genome and its functions. The recent application of microarray and …

The house mouse (Mus musculus) is an exceptional model system, combining genetic
tractability with close evolutionary affinity to humans,. Mouse gestation lasts only 3 weeks …

Maternal morbidity and mortality continue to rise, and pre-eclampsia is a major driver of this
burden. Yet the ability to assess underlying pathophysiology before clinical presentation to …

RNA velocity has opened up new ways of studying cellular differentiation in single-cell RNA-
sequencing data. It describes the rate of gene expression change for an individual gene at a …

RNA Velocity: Molecular Kinetics from Single-Cell RNA-Seq: Molecular Cell Skip to Main
Content Skip to Main Menu Advertisement Molecular Cell This journal offers authors two …

Molecular noise is a natural phenomenon that is inherent to all biological systems,. How
stochastic processes give rise to the robust outcomes that support tissue homeostasis …

Transcript regulation is essential for cell function, and misregulation can lead to disease.
Despite technologies to survey the transcriptome, we lack a comprehensive understanding …

Single-cell RNA sequencing and high-dimensional cytometry can be used to generate
detailed trajectories of dynamic biological processes such as differentiation or development …

Single-cell sequencing methods have enabled in-depth analysis of the diversity of cell types
and cell states in a wide range of organisms. These tools focus predominantly on …