Maternal separation (MS) induces depressive-like behavior and long-term changes in
cognition in rats. Escitalopram is an antidepressant drug shown to reverse the depressive …

Early life stress is a potential precursor of eventual neuropsychiatric diseases and may result
in altered neurodevelopment and function of the hippocampus, which thus provides a site at …

In order to study the gene–environment interaction as well as investigate prophylactic/
ameliorative effects of early intervention on development of adult life psychopathology, we …

There is little research on the effects of adolescent administration of antidepressants on
behavioural function and inflammation in early-life stressed adult mice. Using maternal …

Rationale The neural basis of depression-associated cognitive impairment remains poorly
understood, and the effect of antidepressants on learning and synaptic plasticity in animal …

Early adverse experiences resulting from maternal separation may lead to neuronal cell
death and eventually cause memory impairment. Maternal separation has been used to …

The study of depression is facing major challenges: first, the need to develop new drugs with
a faster onset of action and second, fulfilling the unmet needs of treatment resistant patients …

Introduction Stress impairs cognitive processes and escitalopram affects them in various
ways. The present study has compared the protective effects of two escitalopram doses on …

Hippocampal neurogenesis is potentially implicated in etiology of depression and as the
final common mechanism underlying antidepressant treatments. However, decreased …

Major depressive disorder (MDD) affects 21% of the global population. Chronic exposure to
stressful situations may affect the onset, progression, and biochemical alterations underlying …