Background There is increasing evidence that the pathological overeating underlying some
forms of obesity is compulsive in nature and therefore contains elements of an addictive …

Weight loss is known to alter food intake and drug self-administration, but the neural basis of
this is unknown. Therefore, we studied effects of weight loss on neurochemistry of a brain …

The obesity epidemic is believed to be driven by a food environment that promotes
consumption of inexpensive, convenient, high-calorie, palatable foods. Individual …

Rationale Obesity is a leading public health problem worldwide. Multiple lines of evidence
associate deficits in the brain reward circuit with obesity. Objective Whether alterations in …

We found that development of obesity was coupled with the emergence of a progressively
worsening brain reward deficit. Similar changes in reward homeostasis induced by cocaine …

Increased caloric intake in dietary obesity could be driven by central mechanisms that
regulate reward-seeking behavior. The mesolimbic dopamine system, and the nucleus …

Reports an error in" Dopamine D2 receptors in addiction-like reward dysfunction and
compulsive eating in obese rats" by Paul M. Johnson and Paul J. Kenny (Nature …

In 2010, Johnson and Kenny provided conclusive evidence that extended access to a
Western-style diet promotes addictive-like behavior in rats by downregulating D2 receptors …

Drug addiction and obesity appear to share several properties. Both can be defined as
disorders in which the saliency of a specific type of reward (food or drug) becomes …

Background Obesity is a chronic relapsing disorder that is caused by an excess of caloric
intake relative to energy expenditure. There is growing recognition that food motivation is …