Background Chronic granulomatous disease (CGD), an inherited disorder of the NADPH
oxidase in which phagocytes are defective in generating superoxide anion and downstream …

NADPH oxidase is a critical regulator of both antimicrobial host defense and inflammation.
Activated in nature by microbes and microbial-derived products, the phagocyte NADPH …

Chronic granulomatous disease, an inherited disorder of the NADPH oxidase in which
phagocytes are defective in the generation of superoxide anion and downstream reactive …

Reactive oxygen species (ROS) and oxidative stress are thought to play a central role in the
etiology of cell dysfunction and tissue damage in sepsis. However, there is limited and …

NADPH oxidase is a crucial enzyme in mediating antimicrobial host defense and in
regulating inflammation. Patients with chronic granulomatous disease, an inherited disorder …

In vitro and limited in vivo evidence suggests that reactive oxygen species derived from
NADPH oxidases (NOX-ROS) play an important role in inflammatory responses by …

The leukocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase generates
reactive oxygen species essential in microbial killing and regulation of inflammation …

The phagocyte reduced NAD phosphate (NADPH) oxidase generates superoxide, the
precursor to reactive oxygen species (ROS) that has both antimicrobial and …

Although reactive oxygen species (ROS) produced by NADPH oxidase are known to
regulate inflammatory responses, the impact of ROS on intracellular signaling pathways is …

NADPH oxidase is a multisubunit complex that assembles during phagocytosis to generate
reactive oxygen species. Several components of this complex have been implicated in …