Antioxidants relieve phosphatase inhibition and reduce PDGF signaling in cultured VSMCs and in restenosis
K Kappert, J Sparwel, A Sandin, A Seiler… - … , and vascular biology, 2006 - Am Heart Assoc
Objective—Growth factor–and reactive oxygen species (ROS)-induced activation of VSMCs
is involved in vascular disease. This study investigates whether inhibitory oxidation of …
is involved in vascular disease. This study investigates whether inhibitory oxidation of …
Phospholipase D activation in endothelial cells is redox sensitive
NL Parinandi, WM Scribner, S Vepa, S Shi… - Antioxidants & redox …, 1999 - liebertpub.com
Reactive oxygen species (ROS) are implicated in the pathophysiology of a number of
vascular disorders, including atherosclerosis. Recent studies indicate that ROS modulate …
vascular disorders, including atherosclerosis. Recent studies indicate that ROS modulate …
Endothelial cells negatively modulate reactive oxygen species generation in vascular smooth muscle cells: role of thioredoxin
S Xu, Y He, M Vokurkova, RM Touyz - Hypertension, 2009 - Am Heart Assoc
In intact vessels, endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) act as
an integrated system, possibly through reactive oxygen species (ROS). Using a coculture …
an integrated system, possibly through reactive oxygen species (ROS). Using a coculture …
[HTML][HTML] Matrix metalloproteinase-2-induced epidermal growth factor receptor transactivation impairs redox balance in vascular smooth muscle cells and facilitates …
Increased reactive oxygen species (ROS) formation may enhance matrix metalloproteinase
(MMP)-2 activity and promote cardiovascular dysfunction. We show for the first time that …
(MMP)-2 activity and promote cardiovascular dysfunction. We show for the first time that …
Platelet-derived growth factor–stimulated superoxide anion production modulates activation of transcription factor NF-κB and expression of monocyte chemoattractant …
T Marumo, VB Schini-Kerth, B Fisslthaler, R Busse - Circulation, 1997 - Am Heart Assoc
Background Platelet-derived growth factor (PDGF) and superoxide anion (O2·−) have been
implicated in vascular diseases. We investigated whether PDGF stimulates the production of …
implicated in vascular diseases. We investigated whether PDGF stimulates the production of …
Chrysin restores PDGF-induced inhibition on protein tyrosine phosphatase and reduces PDGF signaling in cultured VSMCs
HM Lo, MW Wu, SL Pan, CY Peng, PH Wu… - The Journal of Nutritional …, 2012 - Elsevier
Previous studies have shown that an increased intake of dietary flavonoids is associated
with a decreased risk of cardiovascular diseases (CVDs). PDGF is a major mitogen for …
with a decreased risk of cardiovascular diseases (CVDs). PDGF is a major mitogen for …
Low Mr protein tyrosine phosphatase inhibits growth and migration of vascular smooth muscle cells induced by platelet-derived growth factor
H Shimizu, M Shiota, N Yamada, K Miyazaki… - Biochemical and …, 2001 - Elsevier
Vascular smooth muscle cell (VSMC) migration and growth are positively regulated by
protein tyrosine phosphorylation. Therefore, a dephosphorylation process controlled by …
protein tyrosine phosphorylation. Therefore, a dephosphorylation process controlled by …
Overexpression of PHGPx inhibits hydroperoxide-induced oxidation, NFκB activation and apoptosis and affects oxLDL-mediated proliferation of rabbit aortic smooth …
R Brigelius-Flohé, S Maurer, K Lötzer, GF Böl… - Atherosclerosis, 2000 - Elsevier
Rabbit abdominal aortic smooth muscle cells (SMC) were stably transfected with the cDNA
of porcine phospholipid hydroperoxide glutathione peroxidase (PHGPx) by means of a …
of porcine phospholipid hydroperoxide glutathione peroxidase (PHGPx) by means of a …
[HTML][HTML] Identification of a protective role for protein phosphatase 1cγ1 against oxidative stress-induced vascular smooth muscle cell apoptosis
I Tchivilev, NR Madamanchi, AE Vendrov… - Journal of Biological …, 2008 - ASBMB
The development of therapeutic strategies to inhibit reactive oxygen species (ROS)-
mediated damage in blood vessels has been limited by a lack of specific targets for …
mediated damage in blood vessels has been limited by a lack of specific targets for …
[HTML][HTML] PPARγ modulates vascular smooth muscle cell phenotype via a protein kinase G-dependent pathway and reduces neointimal hyperplasia after vascular …
HM Yang, BK Kim, JY Kim, YW Kwon, S Jin… - … & molecular medicine, 2013 - nature.com
Vascular smooth muscle cells (VSMCs) undergo phenotypic changes in response to
vascular injury such as angioplasty. Protein kinase G (PKG) has an important role in the …
vascular injury such as angioplasty. Protein kinase G (PKG) has an important role in the …