Fatty acid elongases and desaturases play an important role in hepatic and whole body lipid
composition. We examined the role that key transcription factors played in the control of …

Of the six fatty acid elongase (Elovl) subtypes expressed in mammals, adult rat liver
expresses four subtypes: Elovl-5> Elovl-1= Elovl-2= Elovl-6. Overnight starvation and fish oil …

Hepatic fatty acid elongase-5 (Elovl-5) plays an important role in long chain
monounsaturated and polyunsaturated fatty acid synthesis. Elovl-5 activity is regulated …

Dietary essential fatty acids linoleic acid and α-linolenic acid are converted to arachidonic-,
eicosapentaenoic-, and docosahexaenoic acid under tight regulation by nutritional status …

Elovl-6, a long fatty acid elongase, contributes to de novo synthesis of fatty acids and
regulates hepatic insulin sensitivity. Hepatic regulation of Elovl-6 gene expression in various …

Obesity is a common nutritional problem often associated with diabetes, insulin resistance,
and fatty liver (excess fat deposition in liver). Leptin-deficient Lep ob/Lep ob mice develop …

A growing body of evidence indicates that peroxisome proliferator-activated receptor α
(PPARα) not merely serves as a transcriptional regulator of fatty acid catabolism but also …

Elevated hepatic fatty acid elongase-5 (Elovl5) activity lowers blood glucose in fasted chow-
fed C57BL/6J mice. As high-fat diets induce hyperglycemia and suppress hepatic Elovl5 …

Elongation of very long chain fatty acids (ELOVL) 5 is one of seven mammalian fatty acid
condensing enzymes involved in microsomal fatty acid elongation. To determine the in vivo …

Sterol receptor element-binding protein-1c (SREBP-1c) and peroxisome proliferator-
activated receptor-α (PPAR-α) mRNA expression was assessed in liver as signaling …