Estimation of gene number in mammals is difficult due to the high proportion of noncoding
DNA within the nucleus. In this study, we provide a direct measurement of the number of …

Methylated and non. methylated DNA sequences coexist in many animal gems. In
vertebrates most of the genome is methylated, and non. methylated sequences are reduced …

CpG islands are short stretches of DNA containing a high density of non–methylated CpG
dinucleotides, predominantly associated with coding regions. We have constructed an …

We have investigated the distribution of unmethylated CpG islands in vertebrate genomes
fractionated according to their base composition. Genomes from warm-blooded vertebrates …

CpG islands are useful markers for genes in organisms containing 5-methylcytosine in their
genomes. In addition, CpG islands located in the promoter regions of genes can play …

Although vertebrate DNA is generally depleted in the dinucleotide CpG, it has recently been
shown that some vertebrate genes contain CpG islands, regions of DNA with a high G+ C …

We have shown that human genes associated with CpG islands increase in number as they
increase in% of guanine+ cytosine (GC) levels, and that most genes associated with CpG …

Using fluorescent in situ suppression hybridization to metaphase chromosomes, we have
directly shown that CpG islands are predominantly found in the early replicating (R band) …

Vertebrate genomic DNA is generally CpG depleted 1, 2, possibly because methylation of
cytosines at 80% of CpG dinucleotides results in their frequent mutation to thymine, and thus …

Of the estimated 45 000 CpG islands in the human genome, the overwhelming majority are
found at the 5′ ends of genes and their identification and cloning are proving very useful for …