Previous studies have suggested that the heart may be capable of limited repair and
regeneration in response to a focal injury, while other studies indicate that the mammalian …

Objective Myocardial repair following injury in mammals is restricted such that damaged
areas are replaced by scar tissue, impairing cardiac function. MRL mice exhibit exceptional …

The reaction of cardiac tissue to acute injury involves interacting cascades of cellular and
molecular responses that encompass inflammation, hormonal signaling, extracellular matrix …

The MRL/MpJ mouse strain has been reported to recover after right ventricular cryoinjury
without scar formation or evidence of ventricular dysfunction, suggesting that this mouse …

The cardiac regenerative capacity of MRL/MpJ mouse remains a controversy. Although the
MRL mouse has been reported to exhibit minimal scarring and subsequent cardiac …

Deep tissue wound healing requires a complex sequence of several factors working in
unison to repair the organ at risk. Myocardial infarction (MI) is particularly complex due to …

INTRODUCTION: Murphy Roth Large (MRL) mice have a remarkable regenerative capacity.
A recent report demonstrated rapid cardiac healing in these mice following cryogenically …

BACKGROUND: Myocardial infarcts in mammals heal by scar formation rather than
formation of new muscle tissue. The MRL/MpJ [Murphy Roths large (MRL) derived by the …

Adult humans fail to regenerate their hearts following injury, and this failure to regenerate
myocardium is a leading cause of heart failure and death worldwide. Although all adult …

Background The neonatal heart possesses the unique power to regenerate in response to
resection of the left ventricular apex. We sought to determine whether the type of injury …