Abstract pLink is a search engine for high‐throughput identification of cross‐linked peptides
from their tandem mass spectra, which is the data‐analysis step in chemical cross‐linking of …

Background Chemical cross-linking combined with mass spectrometry (CX-MS) is a high-
throughput approach to studying protein-protein interactions. The number of peptide-peptide …

Protein chemical cross-linking and mass spectrometry enable the analysis of protein–protein
interactions and protein topologies; however, complicated cross-linked peptide spectra …

We describe pLink 2, a search engine with higher speed and reliability for proteome-scale
identification of cross-linked peptides. With a two-stage open search strategy facilitated by …

The increased interest in chemical cross-linking for probing protein structure and interaction
has led to a large increase in literature describing new cross-linkers and search programs …

Background Cross-linking mass spectrometry (XL-MS) is a powerful technique for detecting
protein–protein interactions (PPIs) and modeling protein structures in a high-throughput …

Chemical cross-linking has emerged as a powerful approach for the structural
characterization of proteins and protein complexes. However, the correct identification of …

Crosslinking-mass spectrometry (XL-MS) serves to identify interaction sites between
proteins. Numerous search engines for crosslink identification exist, but lack of ground truth …

Chemical cross-linking combined with mass spectrometry provides a powerful method for
identifying protein− protein interactions and probing the structure of protein complexes. A …

Chemical cross-linking combined with mass spectrometric analysis has become an
important technique for probing protein three-dimensional structure and protein–protein …