The recently cloned GB2 cannabinoid receptor subtype was stably transfected into AtT-20
and Chinese hamster ovary cells to compare the binding and signal transduction properties …

We have investigated the pharmacology of two central human cannabinoid receptor
isoforms, designated CB1 and CB1A, stably expressed in Chinese hamster ovary cell lines …

Two cannabinoid receptors have been identified to date; one is located predominantly in the
central nervous system (CB1), whereas the other is located exclusively in the periphery …

Two types of cannabinoid receptor have been discovered so far, CB1 (2.1: CBD: 1: CB1:),
cloned in 1990, and CB2 (2.1: CBD: 2: CB2:), cloned in 1993. Distinction between these …

Lys192 in the third transmembrane domain of the human GB1 cannabinoid receptor was
converted to an alanine to study its role in receptor recognition and activation by agonists …

We have cloned the peripheral cannabinoid receptor, mCB2, from a mouse splenocyte
cDNA library. The 3.7 kb sequence contains an open reading frame encoding a protein of …

SUMMARY The physiologic activity of (-)-\9-tetrahydrocannabinol, the most active
component of marijuana, and of many synthetic cannabimimetics may be mediated either …

The predominant animal model in which the pharmacology of cannabinoids is studied is the
mouse. Nonetheless, the structure and functional expression of the mouse cannabinoid …

In 1990, there was a breakthrough. Matsuda et al.(3) reported the cloning of a cDNA
encoding a cannabinoid re ceptor (CB1) from a rat brain cDNA library. The CBl recep tor is a …

Two subtypes of the cannabinoid receptor (CB1 and CB2) are expressed in mammalian
tissues. Although selective antagonists are available for each of the subtypes, most of the …