Functional genomics is rapidly progressing towards the elucidation of elements that are
crucial for the cis-regulatory control of gene expression, and population-based studies of …

Variation in gene expression constitutes an important source of biological variability within
and between populations that is likely to contribute significantly to phenotypic diversity …

Much of the recent advances in functional genomics owe to developments in next-
generation sequencing technology, which has contributed to the exponential increase of …

Understanding the consequences of regulatory variation in the human genome remains a
major challenge, with important implications for understanding gene regulation and …

The genetic basis of gene expression variation has long been studied with the aim to
understand the landscape of regulatory variants, but also more recently to assist in the …

Expression levels of human genes vary extensively among individuals. This variation
facilitates analyses of expression levels as quantitative phenotypes in genetic studies where …

Regulatory cis-acting variants account for a large proportion of gene expression variability in
populations. Cis-acting differences can be specifically measured by comparing relative …

We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …

Recent advances in fast and inexpensive DNA sequencing have enabled the extensive
study of genomic and transcriptomic variation in humans. Human genomic variation is …

Inter-individual variation in gene expression has proven to be in part governed by genetic
determinants, which may be trans-or cis-acting. The underlying cause of cis-acting …