WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability
J Dziegielewski, JE Baulch, W Goetz… - Free Radical Biology …, 2008 - Elsevier
Compounds that can protect cells from the effects of radiation are important for clinical use,
in the event of an accidental or terrorist-generated radiation event, and for astronauts …
in the event of an accidental or terrorist-generated radiation event, and for astronauts …
Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells
J Dziegielewski, W Goetz, JS Murley… - Radiation …, 2010 - meridian.allenpress.com
Repair of DNA damage through homologous recombination (HR) pathways plays a crucial
role in maintaining genome stability. However, overstimulation of HR pathways in response …
role in maintaining genome stability. However, overstimulation of HR pathways in response …
Two new faces of amifostine: protector from DNA damage in normal cells and inhibitor of DNA repair in cancer cells
M Hofer, M Falk, D Komůrková, I Falková… - Journal of medicinal …, 2016 - ACS Publications
Amifostine protects normal cells from DNA damage induction by ionizing radiation or
chemotherapeutics, whereas cancer cells typically remain uninfluenced. While confirming …
chemotherapeutics, whereas cancer cells typically remain uninfluenced. While confirming …
Maintenance of Manganese Superoxide Dismutase (SOD2)-Mediated Delayed Radioprotection Induced by Repeated Administration of the Free Thiol Form of …
JS Murley, D Nantajit, KL Baker… - Radiation …, 2008 - meridian.allenpress.com
Abstract Murley, JS, Nantajit, D., Baker, KL, Kataoka, Y., Li, JJ and Grdina, DJ Maintenance
of Manganese Superoxide Dismutase (SOD2)-Mediated Delayed Radioprotection Induced …
of Manganese Superoxide Dismutase (SOD2)-Mediated Delayed Radioprotection Induced …
Concentration-dependent protection against X-ray-induced chromosome aberrations in human lymphocytes by the aminothiol WR-1065
LG Littlefield, EE Joiner, SP Colyer… - Radiation …, 1993 - meridian.allenpress.com
WR-1065, the free-thiol form of WR-2721, has radioprotective effects in various biological
systems. We measured the efficiency of WR-1065 in modifying the induction of chromosome …
systems. We measured the efficiency of WR-1065 in modifying the induction of chromosome …
The effects of cycloheximide and WR-1065 on radiation-induced repair processes: a mechanism for chemoprevention
JS Murley, DJ Grdina - Carcinogenesis, 1995 - academic.oup.com
The effects of cycloheximide (CHX) and 2-[(aminopropyl)-amino] ethanethiol (WR-1065),
each alone or in combination, on radiation-induced mutation induction at the hypoxanthine …
each alone or in combination, on radiation-induced mutation induction at the hypoxanthine …
[HTML][HTML] The radioprotective agent WR1065 protects cells from radiation damage by regulating the activity of the Tip60 acetyltransferase
Y Xu, K Parmar, F Du, BD Price… - International Journal of …, 2011 - ncbi.nlm.nih.gov
Background: The aminothiol WR1065 is a highly effective free radical scavenger which can
protect cells from the cytotoxic effects of ionizing radiation. Currently, WR1065 is used …
protect cells from the cytotoxic effects of ionizing radiation. Currently, WR1065 is used …
Protection against radiation-induced mutagenesis in V79 cells by 2-[(aminopropyl) amino] ethanethiol under conditions of acute hypoxia
DJ Grdina, B Nagy, CK Hill… - Radiation …, 1989 - meridian.allenpress.com
The effects of the radioprotector 2-[(aminopropyl) amino] ethanethiol (WR-1065) on radiation-
induced cell killing and mutagenesis at the hypoxanthine-guanine phosphoribosyl …
induced cell killing and mutagenesis at the hypoxanthine-guanine phosphoribosyl …
Modulation of radiation-induced apoptosis by thiolamines
R L. WARTERS, JC ROBERTS, BH … - … journal of radiation …, 1997 - Taylor & Francis
Exposure to the thiolamine radioprotector N (2-mercaptoethyl)-1, 3-propanediamine (WR-
1065) induced apoptosis in the mouse TB8. 3 hybridoma after a 60-min (LD50= 4.5 mm) or …
1065) induced apoptosis in the mouse TB8. 3 hybridoma after a 60-min (LD50= 4.5 mm) or …
The radioprotector WR1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in V79 cells
DJ Grdina, B Nagy, CK Hill, RL Wells… - …, 1985 - academic.oup.com
Abstract N-(2-mercaptoethyl)-lt3-diaminopropane (WR1065) protects against radiation-
induced cell killing and mutagenesis at the hypoxanthine-guanine phosphoribosyl …
induced cell killing and mutagenesis at the hypoxanthine-guanine phosphoribosyl …