Common brain disorders are associated with heritable patterns of apparent aging of the brain
Common risk factors for psychiatric and other brain disorders are likely to converge on
biological pathways influencing the development and maintenance of brain structure and …
biological pathways influencing the development and maintenance of brain structure and …
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study
Background Brain magnetic resonance imaging (MRI) and cognitive tests can identify
heritable endophenotypes associated with an increased risk of developing stroke, dementia …
heritable endophenotypes associated with an increased risk of developing stroke, dementia …
Three major dimensions of human brain cortical ageing in relation to cognitive decline across the eighth decade of life
Different brain regions can be grouped together, based on cross-sectional correlations
among their cortical characteristics; this patterning has been used to make inferences about …
among their cortical characteristics; this patterning has been used to make inferences about …
[HTML][HTML] Widespread age-related differences in the human brain microstructure revealed by quantitative magnetic resonance imaging
A pressing need exists to disentangle age-related changes from pathologic
neurodegeneration. This study aims to characterize the spatial pattern and age-related …
neurodegeneration. This study aims to characterize the spatial pattern and age-related …
Between destiny and disease: genetics and molecular pathways of human central nervous system aging
C Glorioso, E Sibille - Progress in neurobiology, 2011 - Elsevier
Aging of the human brain is associated with “normal” functional, structural, and molecular
changes that underlie alterations in cognition, memory, mood and motor function, amongst …
changes that underlie alterations in cognition, memory, mood and motor function, amongst …
Accelerated MRI-predicted brain ageing and its associations with cardiometabolic and brain disorders
Brain structure in later life reflects both influences of intrinsic aging and those of lifestyle,
environment and disease. We developed a deep neural network model trained on brain MRI …
environment and disease. We developed a deep neural network model trained on brain MRI …
A common brain network links development, aging, and vulnerability to disease
Several theories link processes of development and aging in humans. In neuroscience, one
model posits for instance that healthy age-related brain degeneration mirrors development …
model posits for instance that healthy age-related brain degeneration mirrors development …
Molecular aging of the brain, neuroplasticity, and vulnerability to depression and other brain-related disorders
E Sibille - Dialogues in clinical neuroscience, 2013 - Taylor & Francis
The increased risk for neurodegenerative and neuropsychiatric disorders associated with
extended lifespan has long suggested mechanistic links between chronological age and …
extended lifespan has long suggested mechanistic links between chronological age and …
Multiregion transcriptomic profiling of the primate brain reveals signatures of aging and the social environment
Aging is accompanied by a host of social and biological changes that correlate with
behavior, cognitive health and susceptibility to neurodegenerative disease. To understand …
behavior, cognitive health and susceptibility to neurodegenerative disease. To understand …
Heterogeneity of structural and functional imaging patterns of advanced brain aging revealed via machine learning methods
Disentangling the heterogeneity of brain aging in cognitively normal older adults is
challenging, as multiple co-occurring pathologic processes result in diverse functional and …
challenging, as multiple co-occurring pathologic processes result in diverse functional and …