Effects of mexiletine on a race-specific mutation in Nav1. 5 associated with long QT syndrome
Mutations in cardiac Nav1. 5 have been associated with LQT syndrome, Brugada syndrome,
and sudden arrhythmia death syndrome. Genetic studies showed that Nav1. 5 mutations …
and sudden arrhythmia death syndrome. Genetic studies showed that Nav1. 5 mutations …
Effects of Mexiletine on a Race-specific Mutation in Nav1.5 Associated With Long QT Syndrome
The voltage-gated sodium channel Nav1. 5 plays an essential role in the generation and
propagation of action potential in cardiomyocytes. Mutations in Nav1. 5 have been …
propagation of action potential in cardiomyocytes. Mutations in Nav1. 5 have been …
Cardiac sodium channel Nav1. 5 mutations and cardiac arrhythmia
W Song, W Shou - Pediatric cardiology, 2012 - Springer
As a major cardiac voltage-gated sodium channel isoform in the heart, the Nav1. 5 channel
is essential for cardiac action potential initiation and subsequent propagation throughout the …
is essential for cardiac action potential initiation and subsequent propagation throughout the …
Structure of human Nav1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome
Z Li, X Jin, T Wu, X Zhao, W Wang… - Proceedings of the …, 2021 - National Acad Sciences
Nav1. 5 is the primary voltage-gated Na+ (Nav) channel in the heart. Mutations of Nav1. 5
are associated with various cardiac disorders exemplified by the type 3 long QT syndrome …
are associated with various cardiac disorders exemplified by the type 3 long QT syndrome …
Long QT syndrome type 3 caused by a PY‐motif mutation leading to altered ubiquitylation and increased expression of Nav1. 5 in knock‐in mice
JS Rougier, M Albesa, CA Remme, J Ogrodnik… - 2012 - Wiley Online Library
Background Congenital long QT syndrome type 3 (LQT3) is a cardiac arrhythmias caused by
gain‐of‐function mutations in SCN5A, the gene encoding the sodium channel Nav1. 5. This …
gain‐of‐function mutations in SCN5A, the gene encoding the sodium channel Nav1. 5. This …
The human Nav1. 5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity
Key points• We investigated how the F1486 deletion LQT3 mutation impairs the functional
properties of the human cardiac voltage‐gated sodium channel (hNav1. 5) and alters action …
properties of the human cardiac voltage‐gated sodium channel (hNav1. 5) and alters action …
Depolarization of the conductance-voltage relationship in the NaV1.5 mutant, E1784K, is due to altered fast inactivation
E1784K is the most common mixed long QT syndrome/Brugada syndrome mutant in the
cardiac voltage-gated sodium channel NaV1. 5. E1784K shifts the midpoint of the channel …
cardiac voltage-gated sodium channel NaV1. 5. E1784K shifts the midpoint of the channel …
Nav1.5 mutations linked to dilated cardiomyopathy phenotypes: Is the gating pore current the missing link?
Nav1. 5 dysfunctions are commonly linked to rhythms disturbances that include type 3 long
QT syndrome (LQT3), Brugada syndrome (BrS), sick sinus syndrome (SSS) and conduction …
QT syndrome (LQT3), Brugada syndrome (BrS), sick sinus syndrome (SSS) and conduction …
Nav1. 5/R1193Q polymorphism is associated with both long QT and Brugada syndromes
H Huang, J Zhao, FZ Barrane, J Champagne… - Canadian Journal of …, 2006 - Elsevier
Background Brugada syndrome (BS) and long QT syndrome (LQTS) are electrical disorders
with a genetic background. They are revealed on surface electrocardiograms as either right …
with a genetic background. They are revealed on surface electrocardiograms as either right …
Biophysical mechanisms of myocardium sodium channelopathies
AK Zaytseva, OE Kulichik, AA Kostareva… - Pflügers Archiv-European …, 2024 - Springer
Genetic variants of gene SCN5A encoding the alpha-subunit of cardiac voltage-gated
sodium channel Nav1. 5 are associated with various diseases, including long QT syndrome …
sodium channel Nav1. 5 are associated with various diseases, including long QT syndrome …