The Fc portion of immunoglobulin (Ig) G harbours a single glycosylation site. Glycan
sialylation is critical for structure and for certain effector functions of IgG. Anti-histone IgG of …

Materials and methods This review focuses on the role of antibody sialylation and methods
for its quantitation. The recent attribution of the anti-inflammatory activity of IgG to the …

Pro-and anti-inflammatory effector functions of IgG antibodies (Abs) depend on their
subclass and Fc glycosylation pattern. Accumulation of non-galactosylated (agalactosylated; …

Antibodies play a critical role in linking the adaptive immune response to the innate immune
system. In humans, antibodies are categorized into five classes, IgG, IgM, IgA, IgE, and IgD …

The long serum t 1/2 of IgGs is ensured by their interaction with the neonatal Fc receptor
(FcRn), which salvages IgG from intracellular degradation. Fc glycosylation is thought not to …

Objective. Decreased clearance of apoptotic cells is suggested to be a major pathogenic
factor in systemic lupus erythematosus (SLE). The aim of this study was to investigate …

IgG antibodies are the basis of some of the most effective therapeutics developed over the
last 20 years. These antibodies are highly specific, have long serum-half lives, and can be …

Human immunoglobulin G (IgG), especially autoantibodies, has major implications for the
diagnosis and management of a wide range of autoimmune diseases. However, some …

Objectives Deficient efferocytosis (ie phagocytic clearance of apoptotic cells) has been
frequently reported in systemic lupus erythematosus (SLE). Todate, patients with primary …

Immunoglobulin (Ig) G antibodies play an important role in the defence against pathogenic
microorganisms, but are also responsible for tissue destruction and inflammation during …