Objective To investigate the role of autophagy in the regulation of cell death in rheumatoid
arthritis synovial fibroblasts (RASFs). Methods RASFs and osteoarthritis synovial fibroblasts …

Introduction Synovial fibroblasts from rheumatoid arthritis show resistance to apoptotic
stimuli, indicating they may be difficult to treat. To clearly understand these mechanisms of …

Background and objective: Mounting studies have illustrated an important role of autophagy
in various diseases, but few studies have reported its contribution to rheumatoid arthritis …

Objective Defective apoptosis contributes to the massive synovial hyperplasia in rheumatoid
arthritis (RA), but the mechanism is largely unknown. To investigate the reasons for the …

Introduction Programmed cell death of intervertebral disc (IVD) cells plays an important role
in IVD degeneration, but the role of autophagy, a closely related cell death event, in IVD …

Objective Autophagy, an evolutionarily conserved process for the bulk degradation of
cytoplasmic components, serves as a cell survival mechanism. The purpose of this study …

Autophagy, a vital mechanism restricted in tissues, exerts its cytoprotective role through the
degradation mechanism of damaged or aging organelles, harmful protein aggregates and …

Objectives Autophagy is a homeostatic process to recycle dispensable and damaged cell
organelles. Dysregulation of autophagic pathways has recently been implicated in the …

Autophagy is considered as an important intracellular mechanism that degrades cytoplasmic
components to furnish additional energy. It has cytoprotective effects through the …

Background Autophagy has emerged as a key mechanism in the survival and function of T
and B lymphocytes, and its activation was involved in apoptosis resistance in rheumatoid …