Astrocytic dysfunction contributes to the molecular pathogenesis of major depressive
disorder (MDD). However, the astrocytic subtype that mainly contributes to MDD etiology …

Depression is a chronic, recurring, and serious mood disorder that afflicts up to 20% of the
global population. The monoamine hypothesis has dominated our understanding of the …

Depressive disorders are complex, multifactorial mental disorders with unknown
neurobiology. Numerous theories aim to explain the pathophysiology. According to the …

The present paper reviews astrocyte pathology in major depressive disorder (MDD) and
proposes that reductions in astrocytes and related markers are key features in the pathology …

Aims Major depressive disorder (MDD) is a prevalent global mental illness with diverse
underlying causes. Despite the availability of first-line antidepressants, approximately 10 …

Astrocytes are an abundant subgroup of cells in the central nervous system (CNS) that play
a critical role in controlling neuronal circuits involved in emotion, learning, and memory. In …

Major depressive disorder (MDD) is one of the most prevalent and disabling mental
disorders, but the genetic etiology remains largely unknown. We performed a meta-analysis …

Major depressive disorder (MDD) is a complicated multifactorial induced disease,
characterized by depressed mood, anhedonia, fatigue, and altered cognitive function …

Astrocytes play crucial roles in brain homeostasis and are regulatory elements of neuronal
and synaptic physiology. Astrocytic alterations have been found in Major Depressive …

Background: Major depressive disorder (MDD) is a serious mental illness characterized by
mood changes and high suicide rates. However, no studies are available to support a blood …