Human induced pluripotent stem cell line with genetically encoded fluorescent voltage indicator generated via CRISPR for action potential assessment post …
YH Sun, HKJ Kao, CW Chang, A Merleev… - Stem Cells, 2020 - academic.oup.com
Genetically encoded fluorescent voltage indicators, such as ArcLight, have been used to
report action potentials (APs) in human induced pluripotent stem cell-derived …
report action potentials (APs) in human induced pluripotent stem cell-derived …
[HTML][HTML] Rapid cellular phenotyping of human pluripotent stem cell-derived cardiomyocytes using a genetically encoded fluorescent voltage sensor
JS Leyton-Mange, RW Mills, VS Macri, MY Jang… - Stem cell reports, 2014 - cell.com
In addition to their promise in regenerative medicine, pluripotent stem cells have proved to
be faithful models of many human diseases. In particular, patient-specific stem cell-derived …
be faithful models of many human diseases. In particular, patient-specific stem cell-derived …
Monitoring human-induced pluripotent stem cell-derived cardiomyocytes with genetically encoded calcium and voltage fluorescent reporters
R Shinnawi, I Huber, L Maizels, N Shaheen… - Stem cell reports, 2015 - cell.com
The advent of the human-induced pluripotent stem cell (hiPSC) technology has transformed
biomedical research, providing new tools for human disease modeling, drug development …
biomedical research, providing new tools for human disease modeling, drug development …
Single-cell RNA-sequencing and optical electrophysiology of human induced pluripotent stem cell-derived cardiomyocytes reveal discordance between cardiac …
SM Biendarra-Tiegs, X Li, D Ye, EB Brandt… - Stem cells and …, 2019 - liebertpub.com
The ability to accurately phenotype cells differentiated from human induced pluripotent stem
cells (hiPSCs) is essential for their application in modeling developmental and disease …
cells (hiPSCs) is essential for their application in modeling developmental and disease …
Human induced pluripotent stem cell-derived cardiac cell sheets expressing genetically encoded voltage indicator for pharmacological and arrhythmia studies
Fulfilling the potential of human induced pluripotent stem cell (hiPSC)-derived
cardiomyocytes for studying conduction and arrhythmogenesis requires development of …
cardiomyocytes for studying conduction and arrhythmogenesis requires development of …
Patch-clamp recording from human induced pluripotent stem cell-derived cardiomyocytes: improving action potential characteristics through dynamic clamp
AO Verkerk, CC Veerman, JG Zegers… - International journal of …, 2017 - mdpi.com
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) hold great
promise for studying inherited cardiac arrhythmias and developing drug therapies to treat …
promise for studying inherited cardiac arrhythmias and developing drug therapies to treat …
Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes
Aims Cardiomyocytes (CMs) generated from human induced pluripotent stem cells (hiPSCs)
are increasingly used in disease modelling and drug evaluation. However, they are typically …
are increasingly used in disease modelling and drug evaluation. However, they are typically …
High-throughput phenotyping of human induced pluripotent stem cell-derived cardiomyocytes and neurons using electric field stimulation and high-speed …
NJ Daily, ZW Du, T Wakatsuki - Assay and drug development …, 2017 - liebertpub.com
Electrophysiology of excitable cells, including muscle cells and neurons, has been
measured by making direct contact with a single cell using a micropipette electrode. To …
measured by making direct contact with a single cell using a micropipette electrode. To …
A near-infrared fluorescent voltage-sensitive dye allows for moderate-throughput electrophysiological analyses of human induced pluripotent stem cell-derived …
A Lopez-Izquierdo, M Warren… - American Journal …, 2014 - journals.physiology.org
Human induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM)-based assays are
emerging as a promising tool for the in vitro preclinical screening of QT interval-prolonging …
emerging as a promising tool for the in vitro preclinical screening of QT interval-prolonging …
Optogenetic reporters delivered as mRNA facilitate repeatable action potential and calcium handling assessment in human iPSC-derived cardiomyocytes
L Yiangou, A Blanch-Asensio, T de Korte, DC Miller… - Stem Cells, 2022 - academic.oup.com
Electrical activity and intracellular Ca2+ transients are key features of cardiomyocytes. They
can be measured using organic voltage-and Ca2+-sensitive dyes but their photostability and …
can be measured using organic voltage-and Ca2+-sensitive dyes but their photostability and …