Mesencephalic dopaminergic neurons were suggested to be a critical physiopathology
substrate for addiction disorders. Among neuroadaptive processes to addictive drugs …

Drug addiction is characterized by persistent behavioral and cellular plasticity throughout
the brain's reward regions. Among the many neuroadaptations that occur following repeated …

Drugs of abuse produce widespread effects on the structure and function of neurons
throughout the brain's reward circuitry, and these changes are believed to underlie the long …

Addiction is characterized by maladaptive decision‐making, a loss of control over drug
consumption and habit‐like drug seeking despite adverse consequences. These cognitive …

Over the past years it has become evident that repeated exposure to a variety of
psychoactive stimulants, like amphetamine, cocaine, MDMA (3, 4-methylenedioxy-N …

Psychostimulants robustly induce alterations in neuronal structural plasticity throughout
brain reward circuits. However, despite our extensive understanding of how these circuits …

Drugs of abuse increase the release of dopamine from mesocorticolimbic neurons in the
ventral tegmental area. Thus, insights into the cytoarchitecture and the synaptic circuitry …

Drug addiction is a chronic, relapsing brain disorder which consists of compulsive patterns
of drug-seeking and taking that occurs at the expense of other activities. The transition from …

Drugs of abuse induce plastic changes in the brain that seem to underlie addictive
phenomena. These plastic changes can be structural (morphological) or synaptic …

A hallmark of drug addiction is the uncontrollable desire to consume drugs at the expense of
severe negative consequences. Moreover, addicts that successfully refrain from drug use …