Genome duplication is essential for cell proliferation, and DNA synthesis is generally
initiated by dedicated replication proteins at specific loci termed origins. In bacteria, the …

Genome replication is a fundamental requirement for the proliferation of all cells. Throughout
the domains of life, conserved DNA replication initiation proteins assemble at specific …

Genome duplication is essential for the proliferation of cellular life and this process is
generally initiated by dedicated replication proteins at chromosome origins. In bacteria, DNA …

Replication of the bacterial chromosome initiates at a single origin of replication that is
called oriC. This occurs via the concerted action of numerous proteins, including DnaA …

Chromosomal replication initiation requires dynamic mechanisms in higher-order
nucleoprotein complexes that are constructed at the origin of replication. In Escherichia coli …

Genome duplication is a critical event in the reproduction cycle of every cell. Because all
daughter cells must inherit a complete genome, chromosome replication is tightly regulated …

In Escherichia coli, ATP-DnaA multimers formed on the replication origin oriC promote
duplex unwinding, which leads to helicase loading. Based on a detailed functional analysis …

Escherichia coli DnaA is the initiator of chromosomal replication. Multiple ATP-DnaA
molecules assemble at the oriC replication origin in a highly regulated manner, and the …

Triggering new rounds of chromosomal DNA replication during the bacterial cell cycle is
exquisitely regulated, ensuring both proper timing and one round per cycle stringency. A …

Chromosome replication is regulated in all organisms at the assembly stage of the
replication machinery at specific origins. In Escherichia coli, the DnaA initiator protein …