Novel quinoline-3-carboxamides (Part 2): Design, optimization and synthesis of quinoline based scaffold as EGFR inhibitors with potent anticancer activity
RM Aly, RAT Serya, AM El-Motwally, A Esmat… - Bioorganic …, 2017 - Elsevier
EGFR has a key role in cell growth. Its mutation and overexpression share in epithelial
malignancies and tumor growth. Quinazoline and quinoline derivatives are common …
malignancies and tumor growth. Quinazoline and quinoline derivatives are common …
Design and Synthesis of some new 2, 4, 6-trisubstituted quinazoline EGFR inhibitors as targeted anticancer agents
HA Allam, EE Aly, AK Farouk, AM El Kerdawy… - Bioorganic …, 2020 - Elsevier
The present study describes the synthesis of 6-bromo-2-(pyridin-3-yl)-4-substituted
quinazolines starting from 4-chloro derivative VI via the reaction with either phenolic …
quinazolines starting from 4-chloro derivative VI via the reaction with either phenolic …
Discovery of a novel series of substituted quinolines acting as anticancer agents and selective EGFR blocker: Molecular docking study
Abstract A Ta 2 O 5-anchored-piperidine-4-carboxylic acid (PPCA) nanoparticle has been
synthesized and characterized. It was then used as a highly effective nanocatalyst for the …
synthesized and characterized. It was then used as a highly effective nanocatalyst for the …
Molecular design and synthesis of certain new quinoline derivatives having potential anticancer activity
DA Ibrahim, DA Abou El Ella, AM El-Motwally… - European Journal of …, 2015 - Elsevier
EGFR, which plays a vital role as a regulator of cell growth, is one of the intensely studied TK
targets of anticancer inhibitors. The most two common anticancer inhibitors are …
targets of anticancer inhibitors. The most two common anticancer inhibitors are …
Design, synthesis, antiproliferative activity and docking studies of quinazoline derivatives bearing 2, 3-dihydro-indole or 1, 2, 3, 4-tetrahydroquinoline as potential …
Y OuYang, W Zou, L Peng, Z Yang, Q Tang… - European Journal of …, 2018 - Elsevier
Eight series of quinazoline derivatives bearing 2, 3-dihydro-indole or 1, 2, 3, 4-
tetrahydroquinoline were designed, synthesized and evaluated for the IC 50 values against …
tetrahydroquinoline were designed, synthesized and evaluated for the IC 50 values against …
Design, synthesis, antiproliferative activity and docking studies of quinazoline derivatives bearing oxazole or imidazole as potential EGFR inhibitors
Y OuYang, C Wang, B Zhao, H Xiong, Z Xiao… - New Journal of …, 2018 - pubs.rsc.org
Six series of quinazoline derivatives bearing oxazole or imidazole (8a–f, 9a–f, 10a–d, 11a–f,
12a–d and 13a–i) were designed, synthesized and their IC50 values evaluated against …
12a–d and 13a–i) were designed, synthesized and their IC50 values evaluated against …
Design, synthesis and assessment of new series of quinazolinone derivatives as EGFR inhibitors along with their cytotoxic evaluation against MCF7 and A549 cancer …
New acetamide (IV ae) and 1, 3-thiazolidinone derivatives (VII ae) were designed,
synthesized and assessed for their cytotoxic activity against MCF-7 and A549 cell lines …
synthesized and assessed for their cytotoxic activity against MCF-7 and A549 cell lines …
Synthesis and biological evaluation of 2-styrylquinolines as antitumour agents and EGFR kinase inhibitors: molecular docking study
MAA El-Sayed, WM El-Husseiny… - Journal of enzyme …, 2018 - Taylor & Francis
Abstract A new series of 4, 6-disubstituted 2-(4-(dimethylamino) styryl) quinoline 4a, b–9a, b
was synthesized by the reaction of 2-(4-(dimethylamino) styryl)-6-substituted quinoline-4 …
was synthesized by the reaction of 2-(4-(dimethylamino) styryl)-6-substituted quinoline-4 …
Design, synthesis, anticancer activity and docking studies of novel quinazoline-based thiazole derivatives as EGFR kinase inhibitors
The in vitro anticancer efficacy of a new series of quinazoline-based thiazole derivatives was
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …
Design, synthesis, and docking studies of quinazoline analogues bearing aryl semicarbazone scaffolds as potent EGFR inhibitors
Two series of quinazoline derivatives bearing aryl semicarbazone scaffolds (9a–o and 10a–
o) were designed, synthesized and evaluated for the IC 50 values against four cancer cell …
o) were designed, synthesized and evaluated for the IC 50 values against four cancer cell …
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