M1 (LPS) macrophages are characterized by a high expression of pro-inflammatory
mediators, and distinct metabolic features that comprise increased glycolysis, a broken TCA …

Salidroside has anti-inflammatory and antiatherosclerotic effects, and mitochondrial
homeostasis imbalance is closely related to cardiovascular disease. The aim of this study …

As a major type of immune cells with heterogeneity and plasticity, macrophages are
classically divided into inflammatory (M1) and alternative/anti-inflammatory (M2) types and …

Obesity and diabetes are associated with excessive inflammation and impaired wound
healing. Increasing evidence suggests that macrophage dysfunction is responsible for these …

Hypercholesterolemia induces intracellular accumulation of cholesterol in macrophages and
other immune cells, causing immunological dysfunctions. On cellular levels, cholesterol …

During the inflammatory response, macrophage phenotypes can be broadly classified as
pro-inflammatory/classically activated “M1”, or pro-resolving/alternatively “M2” …

Mitochondria are master regulators of metabolism. Mitochondria generate ATP by oxidative
phosphorylation using pyruvate (derived from glucose and glycolysis) and fatty acids (FAs) …

Distinct metabolic programs, either energy-consuming anabolism or energy-generating
catabolism, were required for different biological functions. Macrophages can adopt different …

Macrophages generate mitochondrial reactive oxygen species and mitochondrial reactive
electrophilic species as antimicrobials during Toll-like receptor (TLR)-dependent …

Activated macrophages undergo metabolic reprogramming, which drives their pro-
inflammatory phenotype, but the mechanistic basis for this remains obscure. Here, we …