Abstract Aims The common MTNR1B genetic variant rs10830963 is associated with an
increased risk of type 2 diabetes (T2D). To date, no experimental study has tested the effect …

Aims/hypothesis Recently, three groups independently reported that variation in MTNR1B,
the gene encoding melatonin receptor 1B, was associated with an increased risk of type 2 …

Aims/hypothesis We investigated whether variation in MTNR1B, which was recently
identified as a common genetic determinant of fasting glucose levels in healthy, diabetes …

OBJECTIVE Common variants in the melatonin receptor type 1B (MTNR1B) locus have
been shown to increase fasting plasma glucose (FPG) and the risk of type 2 diabetes. The …

Background The MTNR1B gene encodes a receptor for melatonin, a hormone regulating
biorhythms. Disruptions in biorhythms contribute to the development of type 2 diabetes …

The risk of type 2 diabetes (T2D) is increased by abnormalities in sleep quantity and quality,
circadian alignment, and melatonin regulation. A common genetic variant in a receptor for …

OBJECTIVE We tested whether the concurrence of food intake and elevated concentrations
of endogenous melatonin, as occurs with late eating, results in impaired glucose control, in …

Of the associations of genetic variants with type 2 diabetes, the one of an SNP in an intron of
the gene encoding the melatonin receptor 1B (MTNR1B) has been remarkably robust. Work …

The incidence of type 2 diabetes mellitus has markedly increased worldwide over the past
decades. Pancreatic β-cell dysfunction as well as central and peripheral insulin resistance …

Melatonin regulates circadian rhythm, but may also have effects on glucose homeostasis. A
common G‐allele in the MTNR1B locus has been associated with an increased risk of type 2 …