HuR reduces radiation-induced DNA damage by enhancing expression of ARID1A
Tumor suppressor ARID1A, a subunit of the chromatin remodeling complex SWI/SNF,
regulates cell cycle progression, interacts with the tumor suppressor TP53, and prevents …
regulates cell cycle progression, interacts with the tumor suppressor TP53, and prevents …
[HTML][HTML] HuR silencing elicits oxidative stress and DNA damage and sensitizes human triple-negative breast cancer cells to radiotherapy
M Mehta, K Basalingappa, JN Griffith, D Andrade… - Oncotarget, 2016 - ncbi.nlm.nih.gov
HuR is an mRNA-binding protein whose overexpression in cancer cells has been
associated with poor prognosis and resistance to therapy. While reports on HuR …
associated with poor prognosis and resistance to therapy. While reports on HuR …
ARID1A regulates DNA repair through chromatin organization and its deficiency triggers DNA damage-mediated anti-tumor immune response
A Bakr, GD Corte, O Veselinov, S Kelekçi… - Nucleic Acids …, 2024 - academic.oup.com
AT-rich interaction domain protein 1A (ARID1A), a SWI/SNF chromatin remodeling complex
subunit, is frequently mutated across various cancer entities. Loss of ARID1A leads to DNA …
subunit, is frequently mutated across various cancer entities. Loss of ARID1A leads to DNA …
DNA damage-induced activation of ATM promotes β-TRCP-mediated ARID1A ubiquitination and destruction in gastric cancer cells
Z Jiang, T Peng, H Qian, C Lu, F Qiu, S Zhang - Cancer cell international, 2019 - Springer
Background AT-rich interactive domain-containing protein 1A (ARID1A) is a subunit of the
mammary SWI/SNF chromatin remodeling complex and a tumor suppressor protein. The …
mammary SWI/SNF chromatin remodeling complex and a tumor suppressor protein. The …
ARID1A deficiency impairs the DNA damage checkpoint and sensitizes cells to PARP inhibitors
Abstract ARID1A, SWI/SNF chromatin remodeling complex subunit, is a recently identified
tumor suppressor that is mutated in a broad spectrum of human cancers. Thus, it is of …
tumor suppressor that is mutated in a broad spectrum of human cancers. Thus, it is of …
Loss of ARID1A in tumor cells renders selective vulnerability to combined ionizing radiation and PARP inhibitor therapy
Purpose: Somatic inactivating mutations in ARID1A, a component of the SWI/SNF chromatin
remodeling complex, are detected in various types of human malignancies. Loss of ARID1A …
remodeling complex, are detected in various types of human malignancies. Loss of ARID1A …
The emerging roles of ARID1A in tumor suppression
ARID1A has emerged as a tumor suppressor gene, which is mutated in a broad spectrum of
cancers, especially in those arising from ectopic or eutopic endometrium. As a subunit of …
cancers, especially in those arising from ectopic or eutopic endometrium. As a subunit of …
ARID1A and CEBPα cooperatively inhibit UCA1 transcription in breast cancer
X Guo, Y Zhang, A Mayakonda, V Madan, LW Ding… - Oncogene, 2018 - nature.com
As one of the primary members of SWI/SNF chromatin remodeling complexes, ARID1A
contains frequent loss-of-function mutations in many types of cancers. However, the …
contains frequent loss-of-function mutations in many types of cancers. However, the …
Therapeutic targeting of ARID1A-deficient cancer cells with RITA (Reactivating p53 and inducing tumor apoptosis)
Z Wang, X Zhang, Y Luo, Y Song, C Xiang, Y He… - Cell Death & …, 2024 - nature.com
ARID1A, a component of the SWI/SNF chromatin-remodeling complex, is frequently mutated
in various cancer types and has emerged as a potential therapeutic target. In this study, we …
in various cancer types and has emerged as a potential therapeutic target. In this study, we …
Targeting ARID1A-mutant colorectal cancer: depletion of ARID1B increases radiosensitivity and modulates DNA damage response
B Niedermaier, A Sak, E Zernickel, S Xu… - Scientific Reports, 2019 - nature.com
The SWI/SNF chromatin remodeling complex has been found mutated in a wide range of
human cancers, causing alterations in gene expression patterns, proliferation and DNA …
human cancers, causing alterations in gene expression patterns, proliferation and DNA …