Non-spherical micro-and nanoparticles for drug delivery: Progress over 15 years

N Kapate, JR Clegg, S Mitragotri - Advanced Drug Delivery Reviews, 2021 - Elsevier
Shape of particulate drug carries has been identified as a key parameter in determining their
biological outcome. In this review, we analyze the field of particle shape as it shifts from …

Non-spherical micro-and nanoparticles: fabrication, characterization and drug delivery applications

R Mathaes, G Winter, A Besheer… - Expert opinion on drug …, 2015 - Taylor & Francis
Introduction: Micro-and nanoparticles in drug and vaccine delivery have opened up new
possibilities in pharmaceutics. In the past, researchers focused mainly on particle size …

Effect of micro-and nanoparticle shape on biological processes

H Hadji, K Bouchemal - Journal of Controlled Release, 2022 - Elsevier
In the drug delivery field, there is beyond doubt that the shape of micro-and nanoparticles
(M&NPs) critically affects their biological fate. Herein, following an introduction describing …

Non-spherical micro-and nanoparticles in nanomedicine

X Zhu, C Vo, M Taylor, BR Smith - Materials Horizons, 2019 - pubs.rsc.org
Recent studies have revealed the effects of shape on in vivo nanoparticle circulation,
distribution, extravasation, and cellular uptake. Morphology is therefore becoming a key …

Form follows function: nanoparticle shape and its implications for nanomedicine

C Kinnear, TL Moore, L Rodriguez-Lorenzo… - Chemical …, 2017 - ACS Publications
This review is a comprehensive description of the past decade of research into
understanding how the geometry and size of nanoparticles affect their interaction with …

Impact of particle elasticity on particle-based drug delivery systems

AC Anselmo, S Mitragotri - Advanced drug delivery reviews, 2017 - Elsevier
Modification of nano/micro-particle physical parameters (eg size, shape, surface charge) has
proven to be an effective method to enhance their delivery abilities. Recently, advances in …

The effect of particle shape on cellular interaction and drug delivery applications of micro-and nanoparticles

AB Jindal - International journal of pharmaceutics, 2017 - Elsevier
Encapsulation of therapeutic agents in nanoparticles offers several benefits including
improved bioavailability, site specific delivery, reduced toxicity and in vivo stability of …

Designer nanoparticles: incorporating size, shape and triggered release into nanoscale drug carriers

M Caldorera-Moore, N Guimard, L Shi… - Expert opinion on drug …, 2010 - Taylor & Francis
Importance of the field: Although significant progress has been made in delivering
therapeutic agents through micro and nanocarriers, precise control over in vivo …

PRINT: a novel platform toward shape and size specific nanoparticle theranostics

JL Perry, KP Herlihy, ME Napier… - Accounts of chemical …, 2011 - ACS Publications
Nanotheranostics represents the next generation of medicine, fusing nanotechnology,
therapeutics, and diagnostics. By integrating therapeutic and imaging agents into one …

Non-spherical particles for targeted drug delivery

J Chen, NE Clay, N Park, H Kong - Chemical engineering science, 2015 - Elsevier
Nano-and microparticles loaded with various bioimaging contrast agents or therapeutic
molecules have been increasingly used for the diagnosis and treatment of diseases and …