The ability to sense and adjust to the environment is crucial to life. For multicellular
organisms, the ability to respond to external changes is essential not only for survival but …

In the 25 years since its discovery, the nuclear factor-κB (NF-κB) family of transcription
factors has been the subject of intensive research in virtually all areas of biomedical science …

Research on the biological function of nuclear factor-κB (NF-κB), a key mediator of inducible
transcription in the immune system, has traditionally focused on its role in the initiation of …

The mammalian Rel/NF-κB family of transcription factors, including RelA, c-Rel, RelB, NF-
κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central …

NF-κB was first discovered and characterized 25 years ago as a key regulator of inducible
gene expression in the immune system. Thus, it is not surprising that the clearest biological …

NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that
time, it has been found to have a broad role in gene induction in diverse cellular responses …

In the 20 years since its discovery, research into the NF-κB (nuclear factor-κB) family of
transcription factors has revealed an amazing diversity of functions. NF-κB proteins are …

The NF-κB transcription factor was discovered 30 years ago and has since emerged as the
master regulator of inflammation and immune homeostasis. It achieves this status by means …

The transcription factor NF-κB has served as a standard for inducible transcription factors for
more than 20 years. The numerous stimuli that activate NF-κB, and the large number of …

NF-κB is a family of structurally related and evolutionarily conserved transcription factors.
There are five NF-κB proteins in mammals: RelAIp65, RelB, c-Rel, NF-κB1 (p50 and its …